AB099. Improvement of persistent detrusor overactivity after relief of bladder outlet obstruction treated by phytotherapeutic agent

BACKGROUND: Many patients with benign prostatic hyperplasia need treatment for remaining storage symptoms after surgery. Therefore, we evaluated the effect of plant combination on persistent detrusor overactivity (DO) after relief of bladder outlet obstruction (BOO). METHODS: Rats were assigned as three groups: control (n=6), persistent DO (n=6), and persistent DO treated with the plant combination (n=6) groups. Persistent DO after relief of partial BOO was made and 6 of them were orally administered with the plant combination. RESULTS: After 4-week treatment with the plant combination, significantly reduced DO by cystometry was observed compared with persistent DO group. Moreover, oxidative stress, pro-inflammatory cytokines, and M3 muscarinic receptor were significantly increased. Additionally, significantly decreased oxidative stress, pro-inflammatory cytokines, and M3 muscarinic receptor in the bladder were observed after treatment with the plant combination. CONCLUSIONS: Treatment with the plant combination improves persistent DO after relief of BOO mediated by antioxidative and anti-inflammatory effect. Further study is necessary to identify exact mechanism of treatment effect of the plant combination.