Cargando…

Fibroblast recruitment as a tool for ovarian cancer detection and targeted therapy

Metastatic ovarian cancer, the most lethal of gynecologic malignancies, is typically managed by debulking surgery, followed by chemotherapy. However, despite significant efforts, survival rate remains low. We have previously demonstrated, in mouse models, a specific systemic homing of labeled fibrob...

Descripción completa

Detalles Bibliográficos
Autores principales:	Oren, Roni, Addadi, Yoseph, Narunsky Haziza, Lian, Dafni, Hagit, Rotkopf, Ron, Meir, Gila, Fishman, Ami, Neeman, Michal
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2016
Materias:	Tumor Immunology and Microenvironment
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5565769/ https://www.ncbi.nlm.nih.gov/pubmed/27242346 http://dx.doi.org/10.1002/ijc.30209

Ejemplares similares

Inhibition of Nox4‐dependent ROS signaling attenuates prostate fibroblast activation and abrogates stromal‐mediated protumorigenic interactions
por: Sampson, Natalie, et al.
Publicado: (2018)

Cancer‐associated fibroblasts promote PD‐L1 expression in mice cancer cells via secreting CXCL5
por: Li, Ziqian, et al.
Publicado: (2019)

Comparative Tumor Microenvironment Analysis of Primary and Recurrent Ovarian Granulosa Cell Tumors
por: Khlebus, Eleonora, et al.
Publicado: (2023)

The IL‐1/IL‐1R axis induces greater fibroblast‐derived chemokine release in human papillomavirus‐negative compared to positive oropharyngeal cancer
por: Al‐Sahaf, Sarmad, et al.
Publicado: (2018)

High RIG‐I expression in ovarian cancer associates with an immune‐escape signature and poor clinical outcome
por: Wolf, Dominik, et al.
Publicado: (2019)

Colon fibroblasts from Pirc rats (F344/NTac‐Apc (am1137)) exhibit a proliferative and inflammatory phenotype that could support early stages of colon carcinogenesis
por: Tortora, Katia, et al.
Publicado: (2021)

Whole Organ Blood and Lymphatic Vessels Imaging (WOBLI)
por: Oren, Roni, et al.
Publicado: (2018)

Ovarian cancer‐associated mesothelial cells induce acquired platinum‐resistance in peritoneal metastasis via the FN1/Akt signaling pathway
por: Yoshihara, Masato, et al.
Publicado: (2020)

Prediction of Ovarian Follicular Dominance by MRI Phenotyping of Hormonally Induced Vascular Remodeling
por: Fellus-Alyagor, Liat, et al.
Publicado: (2021)

Multimodal Correlative Preclinical Whole Body Imaging and Segmentation
por: Akselrod-Ballin, Ayelet, et al.
Publicado: (2016)

Association of WT1 IgG antibody against WT1 peptide with prolonged survival in glioblastoma multiforme patients vaccinated with WT1 peptide
por: Oji, Yusuke, et al.
Publicado: (2016)

The clinical impact of tumour‐infiltrating lymphocytes in colorectal cancer differs by anatomical subsite: A cohort study
por: Berntsson, Jonna, et al.
Publicado: (2017)

Hyperactive gp130/STAT3‐driven gastric tumourigenesis promotes submucosal tertiary lymphoid structure development
por: Hill, David G., et al.
Publicado: (2018)

Transient receptor potential ankyrin 1 (TRPA1) plays a critical role in a mouse model of cancer pain
por: Antoniazzi, Caren Tatiane De David, et al.
Publicado: (2018)

GITR ligation enhances functionality of tumor‐infiltrating T cells in hepatocellular carcinoma
por: van Beek, Adriaan A., et al.
Publicado: (2019)

Disruption of sialic acid metabolism drives tumor growth by augmenting CD8(+) T cell apoptosis
por: Cornelissen, Lenneke A.M., et al.
Publicado: (2019)

Colitis‐induced colorectal cancer and intestinal epithelial estrogen receptor beta impact gut microbiota diversity
por: Ibrahim, Ahmed, et al.
Publicado: (2019)

Transient immunological and clinical effectiveness of treating mice bearing premalignant oral lesions with PD‐1 antibodies
por: Levingston, Corinne A., et al.
Publicado: (2017)

High number of kinome‐mutations in non‐small cell lung cancer is associated with reduced immune response and poor relapse‐free survival
por: Helland, Å., et al.
Publicado: (2017)

Targeting the arginine metabolic brake enhances immunotherapy for leukaemia
por: Mussai, Francis, et al.
Publicado: (2019)

A pre‐existing coordinated inflammatory microenvironment is associated with complete response of vulvar high‐grade squamous intraepithelial lesions to different forms of immunotherapy
por: Abdulrahman, Ziena, et al.
Publicado: (2020)

Interleukin‐6‐mediated resistance to immunotherapy is linked to impaired myeloid cell function
por: Beyranvand Nejad, Elham, et al.
Publicado: (2020)

A tumor‐targeting nanomedicine carrying the p53 gene crosses the blood–brain barrier and enhances anti‐PD‐1 immunotherapy in mouse models of glioblastoma
por: Kim, Sang‐Soo, et al.
Publicado: (2019)

Transcriptional profiling of breast cancer‐associated lymphatic vessels reveals VCAM‐1 as regulator of lymphatic invasion and permeability
por: Dieterich, Lothar C., et al.
Publicado: (2019)

Oncolytic virotherapy enhances the efficacy of a cancer vaccine by modulating the tumor microenvironment
por: Koske, Iris, et al.
Publicado: (2019)

Immunophenotypes of pancreatic ductal adenocarcinoma: Meta‐analysis of transcriptional subtypes
por: de Santiago, Ines, et al.
Publicado: (2019)

Presence of innate lymphoid cells in pleural effusions of primary and metastatic tumors: Functional analysis and expression of PD‐1 receptor
por: Tumino, Nicola, et al.
Publicado: (2019)

A TLR7 agonist strengthens T and NK cell function during BRAF‐targeted therapy in a preclinical melanoma model
por: Bellmann, Lydia, et al.
Publicado: (2019)

The prognostic value of the tumor–stroma ratio is most discriminative in patients with grade III or triple‐negative breast cancer
por: Vangangelt, Kiki M.H., et al.
Publicado: (2020)

Oncometabolite L‐2‐hydroxyglurate directly induces vasculogenic mimicry through PHLDB2 in renal cell carcinoma
por: Wang, Huan, et al.
Publicado: (2021)

Tumor‐stroma ratio is associated with Miller‐Payne score and pathological response to neoadjuvant chemotherapy in HER2‐negative early breast cancer
por: Hagenaars, Sophie C., et al.
Publicado: (2021)

Mechanical Stress Signaling in Pancreatic Cancer Cells Triggers p38 MAPK- and JNK-Dependent Cytoskeleton Remodeling and Promotes Cell Migration via Rac1/cdc42/Myosin II
por: Kalli, Maria, et al.
Publicado: (2022)

Targeting stromal cell Syndecan‐2 reduces breast tumour growth, metastasis and limits immune evasion
por: Loftus, Paul G., et al.
Publicado: (2020)

The Prognostic Potential of Human Prostate Cancer-Associated Macrophage Subtypes as Revealed by Single-Cell Transcriptomics
por: Siefert, Joseph C., et al.
Publicado: (2021)

NKG2A is a late immune checkpoint on CD8 T cells and marks repeated stimulation and cell division
por: Borst, Linda, et al.
Publicado: (2021)

T-cell Dysfunction upon Expression of MYC with Altered Phosphorylation at Threonine 58 and Serine 62
por: Daniel, Colin J., et al.
Publicado: (2022)

Diurnal Expression of PD-1 on Tumor-Associated Macrophages Underlies the Dosing Time-Dependent Antitumor Effects of the PD-1/PD-L1 Inhibitor BMS-1 in B16/BL6 Melanoma-Bearing Mice
por: Tsuruta, Akito, et al.
Publicado: (2022)

The effects of TNF‐α/TNFR2 in regulatory T cells on the microenvironment and progression of gastric cancer
por: Qu, Yang, et al.
Publicado: (2021)

The immunosuppression pathway of tumor‐associated macrophages is controlled by heme oxygenase‐1 in glioblastoma patients
por: Magri, Sara, et al.
Publicado: (2022)

New insights into glioma frequency maps: From genetic and transcriptomic correlate to survival prediction
por: Bao, Hongbo, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_ifsi6nlrrc7tn4ndf6v4vk14db