Persistently elevated CKMB and negative troponin T in a patient at ischaemic risk with chest pain

Analytical interference in laboratory assays is not only unpredictable but also an underestimated problem. Not recognising these interferences can lead to misdiagnosis and mismanagement of patients. We present a case of a patient with chest pain and ischaemic risk factors with incongruent biochemica...

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Detalles Bibliográficos
Autores principales: Schulenburg, D, Van Jaarsveld, H, Kuyl, JM, de Lange, W
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Clinics Cardive Publishing 2010
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5565915/
https://www.ncbi.nlm.nih.gov/pubmed/20224846
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author Schulenburg, D
Van Jaarsveld, H
Kuyl, JM
de Lange, W
author_facet Schulenburg, D
Van Jaarsveld, H
Kuyl, JM
de Lange, W
author_sort Schulenburg, D
collection PubMed
description Analytical interference in laboratory assays is not only unpredictable but also an underestimated problem. Not recognising these interferences can lead to misdiagnosis and mismanagement of patients. We present a case of a patient with chest pain and ischaemic risk factors with incongruent biochemical results. These results were discovered to be due to the presence of macro-creatine kinase (macro-CK) in vivo interfering with the CKMB activity assay.
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spelling pubmed-55659152017-09-01 Persistently elevated CKMB and negative troponin T in a patient at ischaemic risk with chest pain Schulenburg, D Van Jaarsveld, H Kuyl, JM de Lange, W Cardiovasc J Afr Case Report Analytical interference in laboratory assays is not only unpredictable but also an underestimated problem. Not recognising these interferences can lead to misdiagnosis and mismanagement of patients. We present a case of a patient with chest pain and ischaemic risk factors with incongruent biochemical results. These results were discovered to be due to the presence of macro-creatine kinase (macro-CK) in vivo interfering with the CKMB activity assay. Clinics Cardive Publishing 2010-02 /pmc/articles/PMC5565915/ /pubmed/20224846 Text en Copyright © 2015 Clinics Cardive Publishing http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Schulenburg, D
Van Jaarsveld, H
Kuyl, JM
de Lange, W
Persistently elevated CKMB and negative troponin T in a patient at ischaemic risk with chest pain
title Persistently elevated CKMB and negative troponin T in a patient at ischaemic risk with chest pain
title_full Persistently elevated CKMB and negative troponin T in a patient at ischaemic risk with chest pain
title_fullStr Persistently elevated CKMB and negative troponin T in a patient at ischaemic risk with chest pain
title_full_unstemmed Persistently elevated CKMB and negative troponin T in a patient at ischaemic risk with chest pain
title_short Persistently elevated CKMB and negative troponin T in a patient at ischaemic risk with chest pain
title_sort persistently elevated ckmb and negative troponin t in a patient at ischaemic risk with chest pain
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5565915/
https://www.ncbi.nlm.nih.gov/pubmed/20224846
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