Phosphorylation of AMPK by upstream kinases is required for activity in mammalian cells

AMP-activated protein kinase (AMPK) plays a major role in regulating metabolism and has attracted significant attention as a therapeutic target for treating metabolic disorders. AMPK activity is stimulated more than 100-fold by phosphorylation of threonine 172 (Thr(172)). Binding of AMP to the γ sub...

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Detalles Bibliográficos
Autores principales: Willows, Robin, Sanders, Matthew J., Xiao, Bing, Patel, Bhakti R., Martin, Stephen R., Read, Jon, Wilson, Jon R., Hubbard, Julia, Gamblin, Steven J., Carling, David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Portland Press Ltd. 2017
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5565919/
https://www.ncbi.nlm.nih.gov/pubmed/28694351
http://dx.doi.org/10.1042/BCJ20170458

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