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CTLA4-CD28 chimera gene modification of T cells enhances the therapeutic efficacy of donor lymphocyte infusion for hematological malignancy

Donor lymphocyte infusion (DLI) followed by hematopoietic stem cell transplantation has served as an effective prevention/treatment modality against the relapse of some hematologic tumors, such as chronic myeloid leukemia (CML). However, the therapeutic efficacies of DLI for other types of leukemia,...

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Detalles Bibliográficos
Autores principales: Park, Hyung Bae, Lee, Ji Eun, Oh, Yu Mi, Lee, Sang Jin, Eom, Hyeon-Seok, Choi, Kyungho
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5565951/
https://www.ncbi.nlm.nih.gov/pubmed/28751785
http://dx.doi.org/10.1038/emm.2017.104