Cargando…

Pharmacodynamics of the Orotomides against Aspergillus fumigatus: New Opportunities for Treatment of Multidrug-Resistant Fungal Disease

F901318 is an antifungal agent with a novel mechanism of action and potent activity against Aspergillus spp. An understanding of the pharmacodynamics (PD) of F901318 is required for selection of effective regimens for study in phase II and III clinical trials. Neutropenic murine and rabbit models of...

Descripción completa

Detalles Bibliográficos
Autores principales:	Hope, William W., McEntee, Laura, Livermore, Joanne, Whalley, Sarah, Johnson, Adam, Farrington, Nicola, Kolamunnage-Dona, Ruwanthi, Schwartz, Julie, Kennedy, Anthony, Law, Derek, Birch, Michael, Rex, John H.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Microbiology 2017
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5565967/ https://www.ncbi.nlm.nih.gov/pubmed/28830945 http://dx.doi.org/10.1128/mBio.01157-17

Ejemplares similares

Pharmacodynamics of the Novel Antifungal Agent F901318 for Acute Sinopulmonary Aspergillosis Caused by Aspergillus flavus
por: Negri, Clara E, et al.
Publicado: (2018)

Pharmacodynamics of Isavuconazole for Invasive Mold Disease: Role of Galactomannan for Real-Time Monitoring of Therapeutic Response
por: Kovanda, Laura L., et al.
Publicado: (2017)

Repurposing and Reformulation of the Antiparasitic Agent Flubendazole for Treatment of Cryptococcal Meningoencephalitis, a Neglected Fungal Disease
por: Nixon, Gemma L., et al.
Publicado: (2018)

Experimental Models of Short Courses of Liposomal Amphotericin B for Induction Therapy for Cryptococcal Meningitis
por: Lestner, Jodi, et al.
Publicado: (2017)

Population Pharmacodynamics of Amphotericin B Deoxycholate for Disseminated Infection Caused by Talaromyces marneffei
por: Le, Thuy, et al.
Publicado: (2019)

Fungal siderophore metabolism with a focus on Aspergillus fumigatus
por: Haas, Hubertus
Publicado: (2014)

Fungal Isocyanide Synthases and Xanthocillin Biosynthesis in Aspergillus fumigatus
por: Lim, Fang Yun, et al.
Publicado: (2018)

Flomoxef and fosfomycin in combination for the treatment of neonatal sepsis in the setting of highly prevalent antimicrobial resistance
por: Darlow, Christopher A., et al.
Publicado: (2022)

Assessment of flomoxef combined with amikacin in a hollow-fibre infection model for the treatment of neonatal sepsis in low- and middle-income healthcare settings
por: Darlow, Christopher A, et al.
Publicado: (2022)

Ergothioneine Biosynthesis and Functionality in the Opportunistic Fungal Pathogen, Aspergillus fumigatus
por: Sheridan, Kevin J., et al.
Publicado: (2016)

Population Pharmacokinetic Model and Meta-analysis of Outcomes of Amphotericin B Deoxycholate Use in Adults with Cryptococcal Meningitis
por: Stott, Katharine E., et al.
Publicado: (2018)

Evaluating statistical characteristics of biomarker-guided trial designs
por: Antoniou, Miranta, et al.
Publicado: (2015)

Sample size formula for joint modelling of longitudinal and time-to-event data in clinical trials
por: Powney, Matthew, et al.
Publicado: (2013)

Adjusting for informative missing outcome data in clinical trials with longitudinal study designs
por: Kolamunnage-Dona, Ruwanthi, et al.
Publicado: (2013)

Doxycycline-regulated gene expression in the opportunistic fungal pathogen Aspergillus fumigatus
por: Vogt, Keith, et al.
Publicado: (2005)

Macrophages inhibit Aspergillus fumigatus germination and neutrophil-mediated fungal killing
por: Rosowski, Emily E., et al.
Publicado: (2018)

Infection of burn wound by Aspergillus fumigatus with gross appearance of fungal colonies
por: Que, Anh – Tram, et al.
Publicado: (2019)

Microbe Profile: Aspergillus fumigatus: a saprotrophic and opportunistic fungal pathogen
por: Fang, Wenxia, et al.
Publicado: (2018)

Native valve fungal endocarditis caused by Aspergillus fumigatus: management dilemma
por: Aldosari, Mohammed A, et al.
Publicado: (2020)

Natural products in the predatory defence of the filamentous fungal pathogen Aspergillus fumigatus
por: Boysen, Jana M, et al.
Publicado: (2021)

Biomarker-Guided Adaptive Trial Designs in Phase II and Phase III: A Methodological Review
por: Antoniou, Miranta, et al.
Publicado: (2016)

Modelling variable dropout in randomised controlled trials with longitudinal outcomes: application to the MAGNETIC study
por: Kolamunnage-Dona, Ruwanthi, et al.
Publicado: (2016)

Joint models for longitudinal and time-to-event data: a review of reporting quality with a view to meta-analysis
por: Sudell, Maria, et al.
Publicado: (2016)

Correction to: joint models for longitudinal and time-to-event data: a review of reporting quality with a view to meta-analysis
por: Sudell, Maria, et al.
Publicado: (2018)

Correction: Antoniou, M.; et al. Biomarker-Guided Non-Adaptive Trial Designs in Phase II and Phase III: A Methodological Review. J. Pers. Med. 2017, 7, 1
por: Antoniou, Miranta, et al.
Publicado: (2018)

Correction: Antoniou, M.; et al. Fixed and Adaptive Parallel Subgroup-Specific Design for Survival Outcomes: Power and Sample Size. J. Pers. Med. 2017, 7, 19
por: Antoniou, Miranta, et al.
Publicado: (2018)

Fixed and Adaptive Parallel Subgroup-Specific Design for Survival Outcomes: Power and Sample Size
por: Antoniou, Miranta, et al.
Publicado: (2017)

Time-dependent ROC curve analysis in medical research: current methods and applications
por: Kamarudin, Adina Najwa, et al.
Publicado: (2017)

Biomarker-Guided Non-Adaptive Trial Designs in Phase II and Phase III: A Methodological Review
por: Antoniou, Miranta, et al.
Publicado: (2017)

Aspergillus fumigatus in Poultry
por: Arné, Pascal, et al.
Publicado: (2011)

The Aspergillus fumigatus Dihydroxyacid Dehydratase Ilv3A/IlvC Is Required for Full Virulence
por: Oliver, Jason D., et al.
Publicado: (2012)

A review of the handling of missing longitudinal outcome data in clinical trials
por: Powney, Matthew, et al.
Publicado: (2014)

Aspergillus fumigatus—What Makes the Species a Ubiquitous Human Fungal Pathogen?
por: Kwon-Chung, Kyung J., et al.
Publicado: (2013)

Deciphering metabolic traits of the fungal pathogen Aspergillus fumigatus: redundancy vs. essentiality
por: Amich, Jorge, et al.
Publicado: (2012)

Multiple pulmonary Aspergillus fumigatus cysts and cavities that disappeared with anti‐fungal agents
por: Saitou, Miwako, et al.
Publicado: (2018)

Understanding the Role of Nitronate Monooxygenases in Virulence of the Human Fungal Pathogen Aspergillus fumigatus
por: Nguyen, Phuong Tuyen, et al.
Publicado: (2022)

Regulation of Development in Aspergillus nidulans and Aspergillus fumigatus
por: Yu, Jae-Hyuk
Publicado: (2010)

Joint modelling of time-to-event and multivariate longitudinal outcomes: recent developments and issues
por: Hickey, Graeme L., et al.
Publicado: (2016)

Investigation of 2‐stage meta‐analysis methods for joint longitudinal and time‐to‐event data through simulation and real data application
por: Sudell, Maria, et al.
Publicado: (2017)

joineRML: a joint model and software package for time-to-event and multivariate longitudinal outcomes
por: Hickey, Graeme L., et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_68k4v8rdvinb3l9sfgb44nknh5