Glutamic Pyruvate Transaminase GPT2 Promotes Tumorigenesis of Breast Cancer Cells by Activating Sonic Hedgehog Signaling

Increased glutamine metabolism is a hallmark of cancer. Mitochondrial glutamic pyruvate transaminase (GPT2) catalyzes the reversible transamination between alanine and α-ketoglutarate (α-KG), also known as 2-oxoglutarate, to generate pyruvate and glutamate during cellular glutamine catabolism. Howev...

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Detalles Bibliográficos
Autores principales: Cao, Yuan, Lin, Shu-Hai, Wang, Yongbin, Chin, Y. Eugene, Kang, Lan, Mi, Jun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5566103/
https://www.ncbi.nlm.nih.gov/pubmed/28839461
http://dx.doi.org/10.7150/thno.18992

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