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ANTIPROTOZOAL ACTIVITY OF EXTRACTS OF ELAEODENDRON TRICHOTOMUM (CELASTRACEAE)
BACKGROUND: Chagas disease, amebiasis, giardiasis and trichomoniasis represent a serious health problem in Latin America. The drugs employed to treat these illnesses produce important side effects and resistant strains have appeared. The present study was aimed to evaluate the antiprotozoal activity...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
African Traditional Herbal Medicine Supporters Initiative (ATHMSI)
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5566140/ https://www.ncbi.nlm.nih.gov/pubmed/28852732 http://dx.doi.org/10.21010/ajtcam.v13i4.21 |
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author | Roca-Mézquita, Carolina Graniel-Sabido, Manlio Moo-Puc, Rosa E. Leon-Déniz, Lorena V. Gamboa-León, Rubí Arjona-Ruiz, Carely Tun-Garrido, Juan Mirón-López, Gumersindo Mena-Rejón, Gonzalo J. |
author_facet | Roca-Mézquita, Carolina Graniel-Sabido, Manlio Moo-Puc, Rosa E. Leon-Déniz, Lorena V. Gamboa-León, Rubí Arjona-Ruiz, Carely Tun-Garrido, Juan Mirón-López, Gumersindo Mena-Rejón, Gonzalo J. |
author_sort | Roca-Mézquita, Carolina |
collection | PubMed |
description | BACKGROUND: Chagas disease, amebiasis, giardiasis and trichomoniasis represent a serious health problem in Latin America. The drugs employed to treat these illnesses produce important side effects and resistant strains have appeared. The present study was aimed to evaluate the antiprotozoal activity of leaves, stem bark and root bark of Elaeodendron trichotomum, a celastraceus, that is used in Mexico as an anti-infective in febrile-type diseases. MATERIALS AND METHODS: Dichloromethane and methanol extracts of leaves, bark and roots of Elaeodendron trichotomum were tested against Entamoeba histolytica, Giardia lamblia, Trichomonas vaginalis, and Trypanosoma cruzi. A quantitative HPLC analysis of pristimerin and tingenone was performed. RESULTS: The dichloromethane extract of roots was active against E. histolytica, G. lamblia, T. vaginalis, and T. cruzi, at IC50’s of 0.80, 0.44, 0.46, and 2.68 μg/mL, respectively. The HPLC analysis revealed the presence of tingenone (3.84%) and pristimerin (0.14%). CONCLUSIONS: The dichloromethane extract of the roots bark showed significant activity against all screened protozoa. |
format | Online Article Text |
id | pubmed-5566140 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | African Traditional Herbal Medicine Supporters Initiative (ATHMSI) |
record_format | MEDLINE/PubMed |
spelling | pubmed-55661402017-08-29 ANTIPROTOZOAL ACTIVITY OF EXTRACTS OF ELAEODENDRON TRICHOTOMUM (CELASTRACEAE) Roca-Mézquita, Carolina Graniel-Sabido, Manlio Moo-Puc, Rosa E. Leon-Déniz, Lorena V. Gamboa-León, Rubí Arjona-Ruiz, Carely Tun-Garrido, Juan Mirón-López, Gumersindo Mena-Rejón, Gonzalo J. Afr J Tradit Complement Altern Med Article BACKGROUND: Chagas disease, amebiasis, giardiasis and trichomoniasis represent a serious health problem in Latin America. The drugs employed to treat these illnesses produce important side effects and resistant strains have appeared. The present study was aimed to evaluate the antiprotozoal activity of leaves, stem bark and root bark of Elaeodendron trichotomum, a celastraceus, that is used in Mexico as an anti-infective in febrile-type diseases. MATERIALS AND METHODS: Dichloromethane and methanol extracts of leaves, bark and roots of Elaeodendron trichotomum were tested against Entamoeba histolytica, Giardia lamblia, Trichomonas vaginalis, and Trypanosoma cruzi. A quantitative HPLC analysis of pristimerin and tingenone was performed. RESULTS: The dichloromethane extract of roots was active against E. histolytica, G. lamblia, T. vaginalis, and T. cruzi, at IC50’s of 0.80, 0.44, 0.46, and 2.68 μg/mL, respectively. The HPLC analysis revealed the presence of tingenone (3.84%) and pristimerin (0.14%). CONCLUSIONS: The dichloromethane extract of the roots bark showed significant activity against all screened protozoa. African Traditional Herbal Medicine Supporters Initiative (ATHMSI) 2016-07-03 /pmc/articles/PMC5566140/ /pubmed/28852732 http://dx.doi.org/10.21010/ajtcam.v13i4.21 Text en Copyright: © 2016 Afr. J. Traditional Complementary and Alternative Medicines http://creativecommons.org/licenses/CC-BY/4.0 This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License |
spellingShingle | Article Roca-Mézquita, Carolina Graniel-Sabido, Manlio Moo-Puc, Rosa E. Leon-Déniz, Lorena V. Gamboa-León, Rubí Arjona-Ruiz, Carely Tun-Garrido, Juan Mirón-López, Gumersindo Mena-Rejón, Gonzalo J. ANTIPROTOZOAL ACTIVITY OF EXTRACTS OF ELAEODENDRON TRICHOTOMUM (CELASTRACEAE) |
title | ANTIPROTOZOAL ACTIVITY OF EXTRACTS OF ELAEODENDRON TRICHOTOMUM (CELASTRACEAE) |
title_full | ANTIPROTOZOAL ACTIVITY OF EXTRACTS OF ELAEODENDRON TRICHOTOMUM (CELASTRACEAE) |
title_fullStr | ANTIPROTOZOAL ACTIVITY OF EXTRACTS OF ELAEODENDRON TRICHOTOMUM (CELASTRACEAE) |
title_full_unstemmed | ANTIPROTOZOAL ACTIVITY OF EXTRACTS OF ELAEODENDRON TRICHOTOMUM (CELASTRACEAE) |
title_short | ANTIPROTOZOAL ACTIVITY OF EXTRACTS OF ELAEODENDRON TRICHOTOMUM (CELASTRACEAE) |
title_sort | antiprotozoal activity of extracts of elaeodendron trichotomum (celastraceae) |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5566140/ https://www.ncbi.nlm.nih.gov/pubmed/28852732 http://dx.doi.org/10.21010/ajtcam.v13i4.21 |
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