Dose-related liver injury of Geniposide associated with the alteration in bile acid synthesis and transportation

Fructus Gardenia (FG), containing the major active constituent Geniposide, is widely used in China for medicinal purposes. Currently, clinical reports of FG toxicity have not been published, however, animal studies have shown FG or Geniposide can cause hepatotoxicity in rats. We investigated Genipos...

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Detalles Bibliográficos
Autores principales: Tian, Jingzhuo, Zhu, Jingjing, Yi, Yan, Li, Chunying, Zhang, Yushi, Zhao, Yong, Pan, Chen, Xiang, Shixie, Li, Xiaolong, Li, Guiqin, Newman, John W, Feng, Xiaoyi, Liu, Jing, Han, Jiayin, Wang, Lianmei, Gao, Yue, La Frano, Michael R., Liang, Aihua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5566417/
https://www.ncbi.nlm.nih.gov/pubmed/28827769
http://dx.doi.org/10.1038/s41598-017-09131-2

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