Cargando…
High-intensity training enhances executive function in children in a randomized, placebo-controlled trial
BACKGROUND: Exercise-induced cognitive improvements have traditionally been observed following aerobic exercise interventions; that is, sustained sessions of moderate intensity. Here, we tested the effect of a 6 week high-intensity training (HIT) regimen on measures of cognitive control and working...
Autores principales: | , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
eLife Sciences Publications, Ltd
2017
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5566451/ https://www.ncbi.nlm.nih.gov/pubmed/28825973 http://dx.doi.org/10.7554/eLife.25062 |
_version_ | 1783258555793539072 |
---|---|
author | Moreau, David Kirk, Ian J Waldie, Karen E |
author_facet | Moreau, David Kirk, Ian J Waldie, Karen E |
author_sort | Moreau, David |
collection | PubMed |
description | BACKGROUND: Exercise-induced cognitive improvements have traditionally been observed following aerobic exercise interventions; that is, sustained sessions of moderate intensity. Here, we tested the effect of a 6 week high-intensity training (HIT) regimen on measures of cognitive control and working memory in a multicenter, randomized (1:1 allocation), placebo-controlled trial. METHODS: 318 children aged 7-13 years were randomly assigned to a HIT or an active control group matched for enjoyment and motivation. In the primary analysis, we compared improvements on six cognitive tasks representing two cognitive constructs (N = 305). Secondary outcomes included genetic data and physiological measurements. RESULTS: The 6-week HIT regimen resulted in improvements on measures of cognitive control [BFM = 3.38, g = 0.31 (0.09, 0.54)] and working memory [BFM = 5233.68, g = 0.54 (0.31, 0.77)], moderated by BDNF genotype, with met66 carriers showing larger gains post-exercise than val66 homozygotes. CONCLUSIONS: This study suggests a promising alternative to enhance cognition, via short and potent exercise regimens. FUNDING: Funded by Centre for Brain Research. CLINICAL TRIAL NUMBER: NCT03255499. |
format | Online Article Text |
id | pubmed-5566451 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | eLife Sciences Publications, Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-55664512017-08-25 High-intensity training enhances executive function in children in a randomized, placebo-controlled trial Moreau, David Kirk, Ian J Waldie, Karen E eLife Medicine BACKGROUND: Exercise-induced cognitive improvements have traditionally been observed following aerobic exercise interventions; that is, sustained sessions of moderate intensity. Here, we tested the effect of a 6 week high-intensity training (HIT) regimen on measures of cognitive control and working memory in a multicenter, randomized (1:1 allocation), placebo-controlled trial. METHODS: 318 children aged 7-13 years were randomly assigned to a HIT or an active control group matched for enjoyment and motivation. In the primary analysis, we compared improvements on six cognitive tasks representing two cognitive constructs (N = 305). Secondary outcomes included genetic data and physiological measurements. RESULTS: The 6-week HIT regimen resulted in improvements on measures of cognitive control [BFM = 3.38, g = 0.31 (0.09, 0.54)] and working memory [BFM = 5233.68, g = 0.54 (0.31, 0.77)], moderated by BDNF genotype, with met66 carriers showing larger gains post-exercise than val66 homozygotes. CONCLUSIONS: This study suggests a promising alternative to enhance cognition, via short and potent exercise regimens. FUNDING: Funded by Centre for Brain Research. CLINICAL TRIAL NUMBER: NCT03255499. eLife Sciences Publications, Ltd 2017-08-22 /pmc/articles/PMC5566451/ /pubmed/28825973 http://dx.doi.org/10.7554/eLife.25062 Text en © 2017, Moreau et al http://creativecommons.org/licenses/by/4.0/ http://creativecommons.org/licenses/by/4.0/This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use and redistribution provided that the original author and source are credited. |
spellingShingle | Medicine Moreau, David Kirk, Ian J Waldie, Karen E High-intensity training enhances executive function in children in a randomized, placebo-controlled trial |
title | High-intensity training enhances executive function in children in a randomized, placebo-controlled trial |
title_full | High-intensity training enhances executive function in children in a randomized, placebo-controlled trial |
title_fullStr | High-intensity training enhances executive function in children in a randomized, placebo-controlled trial |
title_full_unstemmed | High-intensity training enhances executive function in children in a randomized, placebo-controlled trial |
title_short | High-intensity training enhances executive function in children in a randomized, placebo-controlled trial |
title_sort | high-intensity training enhances executive function in children in a randomized, placebo-controlled trial |
topic | Medicine |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5566451/ https://www.ncbi.nlm.nih.gov/pubmed/28825973 http://dx.doi.org/10.7554/eLife.25062 |
work_keys_str_mv | AT moreaudavid highintensitytrainingenhancesexecutivefunctioninchildreninarandomizedplacebocontrolledtrial AT kirkianj highintensitytrainingenhancesexecutivefunctioninchildreninarandomizedplacebocontrolledtrial AT waldiekarene highintensitytrainingenhancesexecutivefunctioninchildreninarandomizedplacebocontrolledtrial |