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Accumulation of autophagosomes confers cytotoxicity

Autophagy comprises the processes of autophagosome synthesis and lysosomal degradation. In certain stress conditions, increased autophagosome synthesis may be associated with decreased lysosomal activity, which may result in reduced processing of the excessive autophagosomes by the rate-limiting lys...

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Detalles Bibliográficos
Autores principales:	Button, Robert W., Roberts, Sheridan L., Willis, Thea L., Hanemann, C. Oliver, Luo, Shouqing
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2017
Materias:	Cell Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5566519/ https://www.ncbi.nlm.nih.gov/pubmed/28673965 http://dx.doi.org/10.1074/jbc.M117.782276

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