Chemotherapy with cisplatin: insights into intracellular pH and metabolic landscape of cancer cells in vitro and in vivo

Although cisplatin plays a central role in cancer chemotherapy, the mechanisms of cell response to this drug have been unexplored. The present study demonstrates the relationships between the intracellular pH (pHi), cell bioenergetics and the response of cervical cancer to cisplatin. pHi was measure...

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Detalles Bibliográficos
Autores principales: Shirmanova, Marina V., Druzhkova, Irina N., Lukina, Maria M., Dudenkova, Varvara V., Ignatova, Nadezhda I., Snopova, Ludmila B., Shcheslavskiy, Vladislav I., Belousov, Vsevolod V., Zagaynova, Elena V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5566551/
https://www.ncbi.nlm.nih.gov/pubmed/28827680
http://dx.doi.org/10.1038/s41598-017-09426-4

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