Cargando…

Gabapentin Modulates HCN4 Channel Voltage-Dependence

Gabapentin (GBP) is widely used to treat epilepsy and neuropathic pain. There is evidence that GBP can act on hyperpolarization-activated cation (HCN) channel-mediated I(h) in brain slice experiments. However, evidence showing that GBP directly modulates HCN channels is lacking. The effect of GBP wa...

Descripción completa

Detalles Bibliográficos
Autores principales:	Tae, Han-Shen, Smith, Kelly M., Phillips, A. Marie, Boyle, Kieran A., Li, Melody, Forster, Ian C., Hatch, Robert J., Richardson, Robert, Hughes, David I., Graham, Brett A., Petrou, Steven, Reid, Christopher A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2017
Materias:	Pharmacology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5566583/ https://www.ncbi.nlm.nih.gov/pubmed/28871229 http://dx.doi.org/10.3389/fphar.2017.00554

Ejemplares similares

Antidepressant-like activity of a brain penetrant HCN channel inhibitor in mice
por: Pinares-Garcia, Paulo, et al.
Publicado: (2023)

Selective Blockade of HCN1/HCN2 Channels as a Potential Pharmacological Strategy Against Pain
por: Dini, Leonardo, et al.
Publicado: (2018)

Integrated Allosteric Model of Voltage Gating of Hcn Channels
por: Altomare, Claudia, et al.
Publicado: (2001)

The HCN Channel Blocker ZD7288 Induces Emesis in the Least Shrew (Cryptotis parva)
por: Zhong, W., et al.
Publicado: (2021)

Distinct Populations of HCN Pacemaker Channels Produce Voltage-dependent and Voltage-independent Currents
por: Proenza, Catherine, et al.
Publicado: (2006)

Voltage Sensor Inactivation in Potassium Channels
por: Bähring, Robert, et al.
Publicado: (2012)

Direct regulation of the voltage sensor of HCN channels by membrane lipid compartmentalization
por: Handlin, Lucas J., et al.
Publicado: (2023)

Hysteretic Behavior in Voltage-Gated Channels
por: Villalba-Galea, Carlos A., et al.
Publicado: (2020)

Kinetic Relationship between the Voltage Sensor and the Activation Gate in spHCN Channels
por: Bruening-Wright, Andrew, et al.
Publicado: (2007)

Uncoupling of Voltage- and Ligand-Induced Activation in HCN2 Channels by Glycine Inserts
por: Yüksel, Sezin, et al.
Publicado: (2022)

Changes in peripheral HCN2 channels during persistent inflammation
por: Jansen, L-A. R., et al.
Publicado: (2021)

Voltage Sensor Movement and cAMP Binding Allosterically Regulate an Inherently Voltage-independent Closed−Open Transition in HCN Channels
por: Chen, Shan, et al.
Publicado: (2007)

The HCN Channel Voltage Sensor Undergoes A Large Downward Motion During Hyperpolarization
por: Dai, Gucan, et al.
Publicado: (2019)

Cation and voltage dependence of lidocaine inhibition of the hyperpolarization-activated cyclic nucleotide-gated HCN1 channel
por: Putrenko, Igor, et al.
Publicado: (2017)

Fenestropathy of Voltage-Gated Sodium Channels
por: Gamal El-Din, Tamer M., et al.
Publicado: (2022)

Bipolar switching by HCN voltage sensor underlies hyperpolarization activation
por: Cowgill, John, et al.
Publicado: (2019)

Dual Regulation of Voltage-Sensitive Ion Channels by PIP(2)
por: Rodríguez-Menchaca, Aldo A., et al.
Publicado: (2012)

Prenatal Exposure to Gabapentin Alters the Development of Ventral Midbrain Dopaminergic Neurons
por: Alsanie, Walaa F., et al.
Publicado: (2022)

Hysteresis in the Voltage Dependence of HCN Channels: Conversion between Two Modes Affects Pacemaker Properties
por: Männikkö, Roope, et al.
Publicado: (2005)

Reversal of HCN Channel Voltage Dependence via Bridging of the S4–S5 Linker and Post-S6
por: Prole, David L., et al.
Publicado: (2006)

Charge movement in gating-locked HCN channels reveals weak coupling of voltage sensors and gate
por: Ryu, Sujung, et al.
Publicado: (2012)

Singlet oxygen modification abolishes voltage-dependent inactivation of the sea urchin spHCN channel
por: Idikuda, Vinay, et al.
Publicado: (2018)

Similar voltage-sensor movement in spHCN channels can cause closing, opening, or inactivation
por: Wu, Xiaoan, et al.
Publicado: (2023)

Propranolol Blocks Cardiac and Neuronal Voltage-Gated Sodium Channels
por: Wang, Dao W., et al.
Publicado: (2010)

HCN Channels and Heart Rate
por: Scicchitano, Pietro, et al.
Publicado: (2012)

Review: HCN Channels in the Heart
por: Depuydt, Anne-Sophie, et al.
Publicado: (2022)

Regulation of Voltage-Activated K(+) Channel Gating by Transmembrane β Subunits
por: Sun, Xiaohui, et al.
Publicado: (2012)

Structural Advances in Voltage-Gated Sodium Channels
por: Jiang, Daohua, et al.
Publicado: (2022)

Changes in Local S4 Environment Provide a Voltage-sensing Mechanism for Mammalian Hyperpolarization–activated HCN Channels
por: Bell, Damian C., et al.
Publicado: (2004)

Gabapentin Attenuates Ocular Inflammation: In vitro and In vivo Studies
por: Anfuso, Carmelina D., et al.
Publicado: (2017)

Effects of Topical Gabapentin on Ocular Pain and Tear Secretion
por: Cammalleri, Maurizio, et al.
Publicado: (2021)

Role of voltage-gated proton channel (Hv1) in cancer biology
por: Alvear-Arias, Juan J., et al.
Publicado: (2023)

Cytoplasmic Domains and Voltage-Dependent Potassium Channel Gating
por: Barros, Francisco, et al.
Publicado: (2012)

Voltage-Dependent Gating of hERG Potassium Channels
por: Cheng, Yen May, et al.
Publicado: (2012)

Neurotoxins and Their Binding Areas on Voltage-Gated Sodium Channels
por: Stevens, Marijke, et al.
Publicado: (2011)

Mechanism of Electromechanical Coupling in Voltage-Gated Potassium Channels
por: Blunck, Rikard, et al.
Publicado: (2012)

Inhibition of voltage-gated sodium channels by sumatriptan bioisosteres
por: Carbonara, Roberta, et al.
Publicado: (2015)

Roles for Countercharge in the Voltage Sensor Domain of Ion Channels
por: Groome, James R., et al.
Publicado: (2020)

Editorial: Molecular Mechanisms of Voltage-Gating in Ion Channels
por: Loussouarn, Gildas, et al.
Publicado: (2021)

Molecular Dynamics Simulations of Voltage-Gated Cation Channels: Insights on Voltage-Sensor Domain Function and Modulation
por: Delemotte, Lucie, et al.
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_4smrk984rjd9s606p8s24gde91