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Genome-Wide SNP Analysis Reveals Distinct Origins of Trypanosoma evansi and Trypanosoma equiperdum
Trypanosomes cause a variety of diseases in man and domestic animals in Africa, Latin America, and Asia. In the Trypanozoon subgenus, Trypanosoma brucei gambiense and Trypanosoma brucei rhodesiense cause human African trypanosomiasis, whereas Trypanosoma brucei brucei, Trypanosoma evansi, and Trypan...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5566637/ https://www.ncbi.nlm.nih.gov/pubmed/28541535 http://dx.doi.org/10.1093/gbe/evx102 |
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author | Cuypers, Bart Van den Broeck, Frederik Van Reet, Nick Meehan, Conor J. Cauchard, Julien Wilkes, Jonathan M. Claes, Filip Goddeeris, Bruno Birhanu, Hadush Dujardin, Jean-Claude Laukens, Kris Büscher, Philippe Deborggraeve, Stijn |
author_facet | Cuypers, Bart Van den Broeck, Frederik Van Reet, Nick Meehan, Conor J. Cauchard, Julien Wilkes, Jonathan M. Claes, Filip Goddeeris, Bruno Birhanu, Hadush Dujardin, Jean-Claude Laukens, Kris Büscher, Philippe Deborggraeve, Stijn |
author_sort | Cuypers, Bart |
collection | PubMed |
description | Trypanosomes cause a variety of diseases in man and domestic animals in Africa, Latin America, and Asia. In the Trypanozoon subgenus, Trypanosoma brucei gambiense and Trypanosoma brucei rhodesiense cause human African trypanosomiasis, whereas Trypanosoma brucei brucei, Trypanosoma evansi, and Trypanosoma equiperdum are responsible for nagana, surra, and dourine in domestic animals, respectively. The genetic relationships between T. evansi and T. equiperdum and other Trypanozoon species remain unclear because the majority of phylogenetic analyses has been based on only a few genes. In this study, we have conducted a phylogenetic analysis based on genome-wide SNP analysis comprising 56 genomes from the Trypanozoon subgenus. Our data reveal that T. equiperdum has emerged at least once in Eastern Africa and T. evansi at two independent occasions in Western Africa. The genomes within the T. equiperdum and T. evansi monophyletic clusters show extremely little variation, probably due to the clonal spread linked to the independence from tsetse flies for their transmission. |
format | Online Article Text |
id | pubmed-5566637 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Oxford University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-55666372017-08-25 Genome-Wide SNP Analysis Reveals Distinct Origins of Trypanosoma evansi and Trypanosoma equiperdum Cuypers, Bart Van den Broeck, Frederik Van Reet, Nick Meehan, Conor J. Cauchard, Julien Wilkes, Jonathan M. Claes, Filip Goddeeris, Bruno Birhanu, Hadush Dujardin, Jean-Claude Laukens, Kris Büscher, Philippe Deborggraeve, Stijn Genome Biol Evol Research Article Trypanosomes cause a variety of diseases in man and domestic animals in Africa, Latin America, and Asia. In the Trypanozoon subgenus, Trypanosoma brucei gambiense and Trypanosoma brucei rhodesiense cause human African trypanosomiasis, whereas Trypanosoma brucei brucei, Trypanosoma evansi, and Trypanosoma equiperdum are responsible for nagana, surra, and dourine in domestic animals, respectively. The genetic relationships between T. evansi and T. equiperdum and other Trypanozoon species remain unclear because the majority of phylogenetic analyses has been based on only a few genes. In this study, we have conducted a phylogenetic analysis based on genome-wide SNP analysis comprising 56 genomes from the Trypanozoon subgenus. Our data reveal that T. equiperdum has emerged at least once in Eastern Africa and T. evansi at two independent occasions in Western Africa. The genomes within the T. equiperdum and T. evansi monophyletic clusters show extremely little variation, probably due to the clonal spread linked to the independence from tsetse flies for their transmission. Oxford University Press 2017-05-25 /pmc/articles/PMC5566637/ /pubmed/28541535 http://dx.doi.org/10.1093/gbe/evx102 Text en © The Author 2017. Published by Oxford University Press on behalf of the Society for Molecular Biology and Evolution. http://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com |
spellingShingle | Research Article Cuypers, Bart Van den Broeck, Frederik Van Reet, Nick Meehan, Conor J. Cauchard, Julien Wilkes, Jonathan M. Claes, Filip Goddeeris, Bruno Birhanu, Hadush Dujardin, Jean-Claude Laukens, Kris Büscher, Philippe Deborggraeve, Stijn Genome-Wide SNP Analysis Reveals Distinct Origins of Trypanosoma evansi and Trypanosoma equiperdum |
title | Genome-Wide SNP Analysis Reveals Distinct Origins of Trypanosoma evansi and Trypanosoma equiperdum |
title_full | Genome-Wide SNP Analysis Reveals Distinct Origins of Trypanosoma evansi and Trypanosoma equiperdum |
title_fullStr | Genome-Wide SNP Analysis Reveals Distinct Origins of Trypanosoma evansi and Trypanosoma equiperdum |
title_full_unstemmed | Genome-Wide SNP Analysis Reveals Distinct Origins of Trypanosoma evansi and Trypanosoma equiperdum |
title_short | Genome-Wide SNP Analysis Reveals Distinct Origins of Trypanosoma evansi and Trypanosoma equiperdum |
title_sort | genome-wide snp analysis reveals distinct origins of trypanosoma evansi and trypanosoma equiperdum |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5566637/ https://www.ncbi.nlm.nih.gov/pubmed/28541535 http://dx.doi.org/10.1093/gbe/evx102 |
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