Anorexia of ageing: a key component in the pathogenesis of both sarcopenia and cachexia

The anorexia of aging was first recognized as a physiological syndrome 30 years ago. Its major causes are an alteration in fundal compliance with an increase in antral stretch and enhanced cholecystokinin activity leading to increased satiation.This anorexia leads to weight loss in aging persons and...

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Detalles Bibliográficos
Autor principal: Morley, John E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2017
Materias:
Editorials
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5566640/
https://www.ncbi.nlm.nih.gov/pubmed/28452130
http://dx.doi.org/10.1002/jcsm.12192
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author Morley, John E.
author_facet Morley, John E.
author_sort Morley, John E.
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description The anorexia of aging was first recognized as a physiological syndrome 30 years ago. Its major causes are an alteration in fundal compliance with an increase in antral stretch and enhanced cholecystokinin activity leading to increased satiation.This anorexia leads to weight loss in aging persons and is one of the component causes of the aging related sarcopenia. This physiological anorexia also increases the risk of more severe anorexia when an older person has an increase in inflammatory cytokines such as occurs when they have an illness. This results in an increase in the anorexia due to cachexia in older persons.
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spelling pubmed-55666402017-08-29 Anorexia of ageing: a key component in the pathogenesis of both sarcopenia and cachexia Morley, John E. J Cachexia Sarcopenia Muscle Editorials The anorexia of aging was first recognized as a physiological syndrome 30 years ago. Its major causes are an alteration in fundal compliance with an increase in antral stretch and enhanced cholecystokinin activity leading to increased satiation.This anorexia leads to weight loss in aging persons and is one of the component causes of the aging related sarcopenia. This physiological anorexia also increases the risk of more severe anorexia when an older person has an increase in inflammatory cytokines such as occurs when they have an illness. This results in an increase in the anorexia due to cachexia in older persons. John Wiley and Sons Inc. 2017-04-27 2017-08 /pmc/articles/PMC5566640/ /pubmed/28452130 http://dx.doi.org/10.1002/jcsm.12192 Text en © 2017 The Authors. Journal of Cachexia, Sarcopenia and Muscle published by John Wiley & Sons Ltd on behalf of the Society on Sarcopenia, Cachexia and Wasting Disorders This is an open access article under the terms of the Creative Commons Attribution (http://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Editorials
Morley, John E.
Anorexia of ageing: a key component in the pathogenesis of both sarcopenia and cachexia
title Anorexia of ageing: a key component in the pathogenesis of both sarcopenia and cachexia
title_full Anorexia of ageing: a key component in the pathogenesis of both sarcopenia and cachexia
title_fullStr Anorexia of ageing: a key component in the pathogenesis of both sarcopenia and cachexia
title_full_unstemmed Anorexia of ageing: a key component in the pathogenesis of both sarcopenia and cachexia
title_short Anorexia of ageing: a key component in the pathogenesis of both sarcopenia and cachexia
title_sort anorexia of ageing: a key component in the pathogenesis of both sarcopenia and cachexia
topic Editorials
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5566640/
https://www.ncbi.nlm.nih.gov/pubmed/28452130
http://dx.doi.org/10.1002/jcsm.12192
work_keys_str_mv AT morleyjohne anorexiaofageingakeycomponentinthepathogenesisofbothsarcopeniaandcachexia

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