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Liver stiffness is not associated with short- and long-term plasma HIV RNA replication in immunocompetent patients with HIV infection and with HIV/HCV coinfection

BACKGROUND: Human immunodeficiency virus (HIV) may be directly responsible for liver damage but there are contrasting data regarding the influence of detectable plasma viremia. We analyzed the influence of plasma HIV RNA (pHIV) detectability and of other clinical and viro-immunological variables on...

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Autores principales: Parisi, Saverio Giuseppe, Basso, Monica, Mengoli, Carlo, Scaggiante, Renzo, Andreis, Samantha, Franzetti, Marzia Maria, Cattelan, Anna Maria, Zago, Daniela, Cruciani, Mario, Andreoni, Massimo, Piovesan, Sara, Palù, Giorgio, Alberti, Alfredo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hellenic Society of Gastroenterology 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5566774/
https://www.ncbi.nlm.nih.gov/pubmed/28845109
http://dx.doi.org/10.20524/aog.2017.0175
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author Parisi, Saverio Giuseppe
Basso, Monica
Mengoli, Carlo
Scaggiante, Renzo
Andreis, Samantha
Franzetti, Marzia Maria
Cattelan, Anna Maria
Zago, Daniela
Cruciani, Mario
Andreoni, Massimo
Piovesan, Sara
Palù, Giorgio
Alberti, Alfredo
author_facet Parisi, Saverio Giuseppe
Basso, Monica
Mengoli, Carlo
Scaggiante, Renzo
Andreis, Samantha
Franzetti, Marzia Maria
Cattelan, Anna Maria
Zago, Daniela
Cruciani, Mario
Andreoni, Massimo
Piovesan, Sara
Palù, Giorgio
Alberti, Alfredo
author_sort Parisi, Saverio Giuseppe
collection PubMed
description BACKGROUND: Human immunodeficiency virus (HIV) may be directly responsible for liver damage but there are contrasting data regarding the influence of detectable plasma viremia. We analyzed the influence of plasma HIV RNA (pHIV) detectability and of other clinical and viro-immunological variables on liver stiffness (LS) measurement in adult immunocompetent HIV-monoinfected patients and in patients coinfected with hepatitis C virus (HCV). METHODS: Logistic regression analysis was performed using the value of LS>7.1 kPa as the dependent variable. A linear regression model was applied using LS measurement after log(10) transformation (lkpa) as the dependent variable and we analyzed the predicted values versus the observed lkpa values; pHIV was classified as detectable or undetectable in the 12- and 36-month study periods before LS measurement. RESULTS: We studied 251 patients (178 with HIV monoinfection), most of whom were on antiviral treatment; 36-month study time was available for 154 subjects. The mean CD4+ cell count was 634 cells/mm(3) in HIV-monoinfected patients and 606 cells/mm(3) in coinfected patients. No difference in LS was found between patients with detectable or undetectable pHIV in either the 12- or the 36-month study period before transient elastography. The mean LS was higher in HIV/HCV coinfected patients (P<0.0001) than in the HIV-monoinfected subjects; lkpa was positively correlated with HCV coinfection (P<0.0001) and aspartate aminotransferase levels (P<0.0001). Detectable pHIV failed to reach significance. Eight HIV-monoinfected patients had a predicted LS measurement lower than the observed one, while eight patients had the opposite result. CONCLUSION: LS was not correlated with ongoing HIV replication during the 12- and 36-month study periods in immunocompetent HIV-monoinfected and HIV/HCV-coinfected patients.
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spelling pubmed-55667742017-08-25 Liver stiffness is not associated with short- and long-term plasma HIV RNA replication in immunocompetent patients with HIV infection and with HIV/HCV coinfection Parisi, Saverio Giuseppe Basso, Monica Mengoli, Carlo Scaggiante, Renzo Andreis, Samantha Franzetti, Marzia Maria Cattelan, Anna Maria Zago, Daniela Cruciani, Mario Andreoni, Massimo Piovesan, Sara Palù, Giorgio Alberti, Alfredo Ann Gastroenterol Original Article BACKGROUND: Human immunodeficiency virus (HIV) may be directly responsible for liver damage but there are contrasting data regarding the influence of detectable plasma viremia. We analyzed the influence of plasma HIV RNA (pHIV) detectability and of other clinical and viro-immunological variables on liver stiffness (LS) measurement in adult immunocompetent HIV-monoinfected patients and in patients coinfected with hepatitis C virus (HCV). METHODS: Logistic regression analysis was performed using the value of LS>7.1 kPa as the dependent variable. A linear regression model was applied using LS measurement after log(10) transformation (lkpa) as the dependent variable and we analyzed the predicted values versus the observed lkpa values; pHIV was classified as detectable or undetectable in the 12- and 36-month study periods before LS measurement. RESULTS: We studied 251 patients (178 with HIV monoinfection), most of whom were on antiviral treatment; 36-month study time was available for 154 subjects. The mean CD4+ cell count was 634 cells/mm(3) in HIV-monoinfected patients and 606 cells/mm(3) in coinfected patients. No difference in LS was found between patients with detectable or undetectable pHIV in either the 12- or the 36-month study period before transient elastography. The mean LS was higher in HIV/HCV coinfected patients (P<0.0001) than in the HIV-monoinfected subjects; lkpa was positively correlated with HCV coinfection (P<0.0001) and aspartate aminotransferase levels (P<0.0001). Detectable pHIV failed to reach significance. Eight HIV-monoinfected patients had a predicted LS measurement lower than the observed one, while eight patients had the opposite result. CONCLUSION: LS was not correlated with ongoing HIV replication during the 12- and 36-month study periods in immunocompetent HIV-monoinfected and HIV/HCV-coinfected patients. Hellenic Society of Gastroenterology 2017 2017-07-04 /pmc/articles/PMC5566774/ /pubmed/28845109 http://dx.doi.org/10.20524/aog.2017.0175 Text en Copyright: © Hellenic Society of Gastroenterology http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Parisi, Saverio Giuseppe
Basso, Monica
Mengoli, Carlo
Scaggiante, Renzo
Andreis, Samantha
Franzetti, Marzia Maria
Cattelan, Anna Maria
Zago, Daniela
Cruciani, Mario
Andreoni, Massimo
Piovesan, Sara
Palù, Giorgio
Alberti, Alfredo
Liver stiffness is not associated with short- and long-term plasma HIV RNA replication in immunocompetent patients with HIV infection and with HIV/HCV coinfection
title Liver stiffness is not associated with short- and long-term plasma HIV RNA replication in immunocompetent patients with HIV infection and with HIV/HCV coinfection
title_full Liver stiffness is not associated with short- and long-term plasma HIV RNA replication in immunocompetent patients with HIV infection and with HIV/HCV coinfection
title_fullStr Liver stiffness is not associated with short- and long-term plasma HIV RNA replication in immunocompetent patients with HIV infection and with HIV/HCV coinfection
title_full_unstemmed Liver stiffness is not associated with short- and long-term plasma HIV RNA replication in immunocompetent patients with HIV infection and with HIV/HCV coinfection
title_short Liver stiffness is not associated with short- and long-term plasma HIV RNA replication in immunocompetent patients with HIV infection and with HIV/HCV coinfection
title_sort liver stiffness is not associated with short- and long-term plasma hiv rna replication in immunocompetent patients with hiv infection and with hiv/hcv coinfection
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5566774/
https://www.ncbi.nlm.nih.gov/pubmed/28845109
http://dx.doi.org/10.20524/aog.2017.0175
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