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Liver stiffness is not associated with short- and long-term plasma HIV RNA replication in immunocompetent patients with HIV infection and with HIV/HCV coinfection
BACKGROUND: Human immunodeficiency virus (HIV) may be directly responsible for liver damage but there are contrasting data regarding the influence of detectable plasma viremia. We analyzed the influence of plasma HIV RNA (pHIV) detectability and of other clinical and viro-immunological variables on...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hellenic Society of Gastroenterology
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5566774/ https://www.ncbi.nlm.nih.gov/pubmed/28845109 http://dx.doi.org/10.20524/aog.2017.0175 |
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author | Parisi, Saverio Giuseppe Basso, Monica Mengoli, Carlo Scaggiante, Renzo Andreis, Samantha Franzetti, Marzia Maria Cattelan, Anna Maria Zago, Daniela Cruciani, Mario Andreoni, Massimo Piovesan, Sara Palù, Giorgio Alberti, Alfredo |
author_facet | Parisi, Saverio Giuseppe Basso, Monica Mengoli, Carlo Scaggiante, Renzo Andreis, Samantha Franzetti, Marzia Maria Cattelan, Anna Maria Zago, Daniela Cruciani, Mario Andreoni, Massimo Piovesan, Sara Palù, Giorgio Alberti, Alfredo |
author_sort | Parisi, Saverio Giuseppe |
collection | PubMed |
description | BACKGROUND: Human immunodeficiency virus (HIV) may be directly responsible for liver damage but there are contrasting data regarding the influence of detectable plasma viremia. We analyzed the influence of plasma HIV RNA (pHIV) detectability and of other clinical and viro-immunological variables on liver stiffness (LS) measurement in adult immunocompetent HIV-monoinfected patients and in patients coinfected with hepatitis C virus (HCV). METHODS: Logistic regression analysis was performed using the value of LS>7.1 kPa as the dependent variable. A linear regression model was applied using LS measurement after log(10) transformation (lkpa) as the dependent variable and we analyzed the predicted values versus the observed lkpa values; pHIV was classified as detectable or undetectable in the 12- and 36-month study periods before LS measurement. RESULTS: We studied 251 patients (178 with HIV monoinfection), most of whom were on antiviral treatment; 36-month study time was available for 154 subjects. The mean CD4+ cell count was 634 cells/mm(3) in HIV-monoinfected patients and 606 cells/mm(3) in coinfected patients. No difference in LS was found between patients with detectable or undetectable pHIV in either the 12- or the 36-month study period before transient elastography. The mean LS was higher in HIV/HCV coinfected patients (P<0.0001) than in the HIV-monoinfected subjects; lkpa was positively correlated with HCV coinfection (P<0.0001) and aspartate aminotransferase levels (P<0.0001). Detectable pHIV failed to reach significance. Eight HIV-monoinfected patients had a predicted LS measurement lower than the observed one, while eight patients had the opposite result. CONCLUSION: LS was not correlated with ongoing HIV replication during the 12- and 36-month study periods in immunocompetent HIV-monoinfected and HIV/HCV-coinfected patients. |
format | Online Article Text |
id | pubmed-5566774 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Hellenic Society of Gastroenterology |
record_format | MEDLINE/PubMed |
spelling | pubmed-55667742017-08-25 Liver stiffness is not associated with short- and long-term plasma HIV RNA replication in immunocompetent patients with HIV infection and with HIV/HCV coinfection Parisi, Saverio Giuseppe Basso, Monica Mengoli, Carlo Scaggiante, Renzo Andreis, Samantha Franzetti, Marzia Maria Cattelan, Anna Maria Zago, Daniela Cruciani, Mario Andreoni, Massimo Piovesan, Sara Palù, Giorgio Alberti, Alfredo Ann Gastroenterol Original Article BACKGROUND: Human immunodeficiency virus (HIV) may be directly responsible for liver damage but there are contrasting data regarding the influence of detectable plasma viremia. We analyzed the influence of plasma HIV RNA (pHIV) detectability and of other clinical and viro-immunological variables on liver stiffness (LS) measurement in adult immunocompetent HIV-monoinfected patients and in patients coinfected with hepatitis C virus (HCV). METHODS: Logistic regression analysis was performed using the value of LS>7.1 kPa as the dependent variable. A linear regression model was applied using LS measurement after log(10) transformation (lkpa) as the dependent variable and we analyzed the predicted values versus the observed lkpa values; pHIV was classified as detectable or undetectable in the 12- and 36-month study periods before LS measurement. RESULTS: We studied 251 patients (178 with HIV monoinfection), most of whom were on antiviral treatment; 36-month study time was available for 154 subjects. The mean CD4+ cell count was 634 cells/mm(3) in HIV-monoinfected patients and 606 cells/mm(3) in coinfected patients. No difference in LS was found between patients with detectable or undetectable pHIV in either the 12- or the 36-month study period before transient elastography. The mean LS was higher in HIV/HCV coinfected patients (P<0.0001) than in the HIV-monoinfected subjects; lkpa was positively correlated with HCV coinfection (P<0.0001) and aspartate aminotransferase levels (P<0.0001). Detectable pHIV failed to reach significance. Eight HIV-monoinfected patients had a predicted LS measurement lower than the observed one, while eight patients had the opposite result. CONCLUSION: LS was not correlated with ongoing HIV replication during the 12- and 36-month study periods in immunocompetent HIV-monoinfected and HIV/HCV-coinfected patients. Hellenic Society of Gastroenterology 2017 2017-07-04 /pmc/articles/PMC5566774/ /pubmed/28845109 http://dx.doi.org/10.20524/aog.2017.0175 Text en Copyright: © Hellenic Society of Gastroenterology http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Parisi, Saverio Giuseppe Basso, Monica Mengoli, Carlo Scaggiante, Renzo Andreis, Samantha Franzetti, Marzia Maria Cattelan, Anna Maria Zago, Daniela Cruciani, Mario Andreoni, Massimo Piovesan, Sara Palù, Giorgio Alberti, Alfredo Liver stiffness is not associated with short- and long-term plasma HIV RNA replication in immunocompetent patients with HIV infection and with HIV/HCV coinfection |
title | Liver stiffness is not associated with short- and long-term plasma HIV RNA replication in immunocompetent patients with HIV infection and with HIV/HCV coinfection |
title_full | Liver stiffness is not associated with short- and long-term plasma HIV RNA replication in immunocompetent patients with HIV infection and with HIV/HCV coinfection |
title_fullStr | Liver stiffness is not associated with short- and long-term plasma HIV RNA replication in immunocompetent patients with HIV infection and with HIV/HCV coinfection |
title_full_unstemmed | Liver stiffness is not associated with short- and long-term plasma HIV RNA replication in immunocompetent patients with HIV infection and with HIV/HCV coinfection |
title_short | Liver stiffness is not associated with short- and long-term plasma HIV RNA replication in immunocompetent patients with HIV infection and with HIV/HCV coinfection |
title_sort | liver stiffness is not associated with short- and long-term plasma hiv rna replication in immunocompetent patients with hiv infection and with hiv/hcv coinfection |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5566774/ https://www.ncbi.nlm.nih.gov/pubmed/28845109 http://dx.doi.org/10.20524/aog.2017.0175 |
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