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Androgen receptor gene CAG and GGN repeat lengths as predictors of recovery of spermatogenesis following testicular germ cell cancer treatment
Spermatogenesis is an androgen-regulated process that depends on the action of androgen receptor (AR). Sperm production may be affected in men treated for testicular cancer (TC), and it is important to identify the factors influencing the timing of spermatogenesis recovery following cancer treatment...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Medknow Publications & Media Pvt Ltd
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5566846/ https://www.ncbi.nlm.nih.gov/pubmed/27873769 http://dx.doi.org/10.4103/1008-682X.191126 |
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author | Bogefors, Karolina Giwercman, Yvonne Lundberg Eberhard, Jakob Stahl, Olof Cavallin-Stahl, Eva Cohn-Cedermark, Gabriella Arver, Stefan Giwercman, Aleksander |
author_facet | Bogefors, Karolina Giwercman, Yvonne Lundberg Eberhard, Jakob Stahl, Olof Cavallin-Stahl, Eva Cohn-Cedermark, Gabriella Arver, Stefan Giwercman, Aleksander |
author_sort | Bogefors, Karolina |
collection | PubMed |
description | Spermatogenesis is an androgen-regulated process that depends on the action of androgen receptor (AR). Sperm production may be affected in men treated for testicular cancer (TC), and it is important to identify the factors influencing the timing of spermatogenesis recovery following cancer treatment. It is known that the CAG and GGN repeat numbers affect the activity of the AR; therefore, the aim of this study is to investigate if the CAG and GGN polymorphisms in the AR gene predict recovery of sperm production after TC treatment. TC patients (n = 130) delivered ejaculates at the following time points: postorchiectomy and at 6, 12, 24, 36, and 60 months posttherapy (T0, T6, T12, T24, T36, and T60). The CAG lengths were categorized into three groups, <22 CAG, 22–23 CAG, and >23 CAG, and the GGN tracts were also categorized into three groups, <23 GGN, 23 GGN, and >23 GGN. At T12, men with 22–23 CAG presented with a statistically significantly (P = 0.045) lower sperm concentration than those with other CAG numbers (8.4 × 10(6) ml(−1) vs 16 × 10(6) ml(−1); 95% CI: 1.01–2.65). This association was robust to omitting adjustment for treatment type and sperm concentration at T0 (P = 0.021; 3.7 × 10(6) ml(−1) vs 10 × 10(6) ml(−1); 95% CI: 1.13–4.90). The same trends were observed for total sperm number. The least active AR variant seems to be associated with a more rapid recovery of spermatogenesis. This finding adds to our understanding of the biology of postcancer therapy recovery of fertility in males and has clinical implications. |
format | Online Article Text |
id | pubmed-5566846 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Medknow Publications & Media Pvt Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-55668462017-09-02 Androgen receptor gene CAG and GGN repeat lengths as predictors of recovery of spermatogenesis following testicular germ cell cancer treatment Bogefors, Karolina Giwercman, Yvonne Lundberg Eberhard, Jakob Stahl, Olof Cavallin-Stahl, Eva Cohn-Cedermark, Gabriella Arver, Stefan Giwercman, Aleksander Asian J Androl Original Article Spermatogenesis is an androgen-regulated process that depends on the action of androgen receptor (AR). Sperm production may be affected in men treated for testicular cancer (TC), and it is important to identify the factors influencing the timing of spermatogenesis recovery following cancer treatment. It is known that the CAG and GGN repeat numbers affect the activity of the AR; therefore, the aim of this study is to investigate if the CAG and GGN polymorphisms in the AR gene predict recovery of sperm production after TC treatment. TC patients (n = 130) delivered ejaculates at the following time points: postorchiectomy and at 6, 12, 24, 36, and 60 months posttherapy (T0, T6, T12, T24, T36, and T60). The CAG lengths were categorized into three groups, <22 CAG, 22–23 CAG, and >23 CAG, and the GGN tracts were also categorized into three groups, <23 GGN, 23 GGN, and >23 GGN. At T12, men with 22–23 CAG presented with a statistically significantly (P = 0.045) lower sperm concentration than those with other CAG numbers (8.4 × 10(6) ml(−1) vs 16 × 10(6) ml(−1); 95% CI: 1.01–2.65). This association was robust to omitting adjustment for treatment type and sperm concentration at T0 (P = 0.021; 3.7 × 10(6) ml(−1) vs 10 × 10(6) ml(−1); 95% CI: 1.13–4.90). The same trends were observed for total sperm number. The least active AR variant seems to be associated with a more rapid recovery of spermatogenesis. This finding adds to our understanding of the biology of postcancer therapy recovery of fertility in males and has clinical implications. Medknow Publications & Media Pvt Ltd 2017 2016-11-18 /pmc/articles/PMC5566846/ /pubmed/27873769 http://dx.doi.org/10.4103/1008-682X.191126 Text en Copyright: © The Author(s)(2017) http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms. |
spellingShingle | Original Article Bogefors, Karolina Giwercman, Yvonne Lundberg Eberhard, Jakob Stahl, Olof Cavallin-Stahl, Eva Cohn-Cedermark, Gabriella Arver, Stefan Giwercman, Aleksander Androgen receptor gene CAG and GGN repeat lengths as predictors of recovery of spermatogenesis following testicular germ cell cancer treatment |
title | Androgen receptor gene CAG and GGN repeat lengths as predictors of recovery of spermatogenesis following testicular germ cell cancer treatment |
title_full | Androgen receptor gene CAG and GGN repeat lengths as predictors of recovery of spermatogenesis following testicular germ cell cancer treatment |
title_fullStr | Androgen receptor gene CAG and GGN repeat lengths as predictors of recovery of spermatogenesis following testicular germ cell cancer treatment |
title_full_unstemmed | Androgen receptor gene CAG and GGN repeat lengths as predictors of recovery of spermatogenesis following testicular germ cell cancer treatment |
title_short | Androgen receptor gene CAG and GGN repeat lengths as predictors of recovery of spermatogenesis following testicular germ cell cancer treatment |
title_sort | androgen receptor gene cag and ggn repeat lengths as predictors of recovery of spermatogenesis following testicular germ cell cancer treatment |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5566846/ https://www.ncbi.nlm.nih.gov/pubmed/27873769 http://dx.doi.org/10.4103/1008-682X.191126 |
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