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Alteration of retinal layers in healthy subjects over 60 years of age until nonagenarians

PURPOSE: To assess alterations of retinal layers in healthy subjects over 60 years old. METHODS: Retinal layers of 160 healthy subjects (aged 60–100 years) without any retinal pathology were imaged using spectral domain optical coherence tomography. Mean thickness of retinal nerve fiber layer, gangl...

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Autores principales: Altay, Lebriz, Jahn, Cheryl, Arikan Yorgun, Mücella, Caramoy, Albert, Schick, Tina, Hoyng, Carel B, den Hollander, Anneke I, Fauser, Sascha
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5566895/
https://www.ncbi.nlm.nih.gov/pubmed/28860699
http://dx.doi.org/10.2147/OPTH.S137223
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author Altay, Lebriz
Jahn, Cheryl
Arikan Yorgun, Mücella
Caramoy, Albert
Schick, Tina
Hoyng, Carel B
den Hollander, Anneke I
Fauser, Sascha
author_facet Altay, Lebriz
Jahn, Cheryl
Arikan Yorgun, Mücella
Caramoy, Albert
Schick, Tina
Hoyng, Carel B
den Hollander, Anneke I
Fauser, Sascha
author_sort Altay, Lebriz
collection PubMed
description PURPOSE: To assess alterations of retinal layers in healthy subjects over 60 years old. METHODS: Retinal layers of 160 healthy subjects (aged 60–100 years) without any retinal pathology were imaged using spectral domain optical coherence tomography. Mean thickness of retinal nerve fiber layer, ganglion cell/inner plexiform layer (GCLIPL), inner nuclear layer, outer plexiform layer/outer nuclear layer, photoreceptor complex (PR) and retinal thickness (RT) were measured in a 3.45 mm grid. Correlations between age and layers were estimated and linear regression equations were calculated. Different age-groups (60–69, 70–79, 80–89 years and nonagenarians, each group with 40 participants) were compared. RESULTS: Significant age-thickness correlations were observed for GCLIPL (P<0.001, r=−0.394), PR (P<0.001, r=−0.370) and RT (P<0.001, r=−0.290). A comparison between age groups 60–69 years and nonagenarians showed no significant thickness alteration of retinal nerve fiber layer (21.80±2.18 μm vs 22.82±2.97 μm, P=0.163), inner nuclear layer (37.23±3.02 μm vs 36.01±3.24 μm, P=0.07) and outer plexiform layer/outer nuclear layer (104.95±6.56 μm vs 104.23±7.59 μm, P=0.567), while GCLIPL (83.35±7.35 μm vs 74.38±9.09 μm), PR (83.03±3.31 μm vs 79.34±2.09 μm) and RT (330.64±12.63 μm vs 316.83±18.35 μm) showed a significant decrease (P<0.001 for all). CONCLUSION: Our study provides normative data of alterations of retinal layers for persons aged 60 years to nonagenarians and indicates a continuous decrease of RT, PR, and GCLIPL. This data may be useful for clinical trials investigating macular diseases in older patients.
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spelling pubmed-55668952017-08-31 Alteration of retinal layers in healthy subjects over 60 years of age until nonagenarians Altay, Lebriz Jahn, Cheryl Arikan Yorgun, Mücella Caramoy, Albert Schick, Tina Hoyng, Carel B den Hollander, Anneke I Fauser, Sascha Clin Ophthalmol Original Research PURPOSE: To assess alterations of retinal layers in healthy subjects over 60 years old. METHODS: Retinal layers of 160 healthy subjects (aged 60–100 years) without any retinal pathology were imaged using spectral domain optical coherence tomography. Mean thickness of retinal nerve fiber layer, ganglion cell/inner plexiform layer (GCLIPL), inner nuclear layer, outer plexiform layer/outer nuclear layer, photoreceptor complex (PR) and retinal thickness (RT) were measured in a 3.45 mm grid. Correlations between age and layers were estimated and linear regression equations were calculated. Different age-groups (60–69, 70–79, 80–89 years and nonagenarians, each group with 40 participants) were compared. RESULTS: Significant age-thickness correlations were observed for GCLIPL (P<0.001, r=−0.394), PR (P<0.001, r=−0.370) and RT (P<0.001, r=−0.290). A comparison between age groups 60–69 years and nonagenarians showed no significant thickness alteration of retinal nerve fiber layer (21.80±2.18 μm vs 22.82±2.97 μm, P=0.163), inner nuclear layer (37.23±3.02 μm vs 36.01±3.24 μm, P=0.07) and outer plexiform layer/outer nuclear layer (104.95±6.56 μm vs 104.23±7.59 μm, P=0.567), while GCLIPL (83.35±7.35 μm vs 74.38±9.09 μm), PR (83.03±3.31 μm vs 79.34±2.09 μm) and RT (330.64±12.63 μm vs 316.83±18.35 μm) showed a significant decrease (P<0.001 for all). CONCLUSION: Our study provides normative data of alterations of retinal layers for persons aged 60 years to nonagenarians and indicates a continuous decrease of RT, PR, and GCLIPL. This data may be useful for clinical trials investigating macular diseases in older patients. Dove Medical Press 2017-08-16 /pmc/articles/PMC5566895/ /pubmed/28860699 http://dx.doi.org/10.2147/OPTH.S137223 Text en © 2017 Altay et al. This work is published and licensed by Dove Medical Press Limited The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.
spellingShingle Original Research
Altay, Lebriz
Jahn, Cheryl
Arikan Yorgun, Mücella
Caramoy, Albert
Schick, Tina
Hoyng, Carel B
den Hollander, Anneke I
Fauser, Sascha
Alteration of retinal layers in healthy subjects over 60 years of age until nonagenarians
title Alteration of retinal layers in healthy subjects over 60 years of age until nonagenarians
title_full Alteration of retinal layers in healthy subjects over 60 years of age until nonagenarians
title_fullStr Alteration of retinal layers in healthy subjects over 60 years of age until nonagenarians
title_full_unstemmed Alteration of retinal layers in healthy subjects over 60 years of age until nonagenarians
title_short Alteration of retinal layers in healthy subjects over 60 years of age until nonagenarians
title_sort alteration of retinal layers in healthy subjects over 60 years of age until nonagenarians
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5566895/
https://www.ncbi.nlm.nih.gov/pubmed/28860699
http://dx.doi.org/10.2147/OPTH.S137223
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