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Vascular channels in metacarpophalangeal joints: a comparative histologic and high-resolution imaging study

We evaluated whether cortical interruptions classified as vascular channel (VC) on high-resolution peripheral quantitative computed tomography (HR-pQCT) could be confirmed by histology. We subsequently evaluated the image characteristics of histologically identified VCs on matched single and multipl...

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Autores principales: Scharmga, A., Keller, K. K., Peters, M., van Tubergen, A., van den Bergh, J. P., van Rietbergen, B., Weijers, R., Loeffen, D., Hauge, E. M., Geusens, P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5566954/
https://www.ncbi.nlm.nih.gov/pubmed/28827584
http://dx.doi.org/10.1038/s41598-017-09363-2
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author Scharmga, A.
Keller, K. K.
Peters, M.
van Tubergen, A.
van den Bergh, J. P.
van Rietbergen, B.
Weijers, R.
Loeffen, D.
Hauge, E. M.
Geusens, P.
author_facet Scharmga, A.
Keller, K. K.
Peters, M.
van Tubergen, A.
van den Bergh, J. P.
van Rietbergen, B.
Weijers, R.
Loeffen, D.
Hauge, E. M.
Geusens, P.
author_sort Scharmga, A.
collection PubMed
description We evaluated whether cortical interruptions classified as vascular channel (VC) on high-resolution peripheral quantitative computed tomography (HR-pQCT) could be confirmed by histology. We subsequently evaluated the image characteristics of histologically identified VCs on matched single and multiplane HR-pQCT images. Four 3-mm thick portions in three anatomic metacarpophalangeal joint specimens were selected for histologic sectioning. First, VCs identified with HR-pQCT were examined for confirmation on histology. Second and independently, VCs identified by histology were matched to single and multiplane HR-pQCT images to assess for presence of cortical interruptions. Only one out of five cortical interruptions suggestive for VC on HR-pQCT could be confirmed on histology. In contrast, 52 VCs were identified by histology of which 39 (75%) could be classified as cortical interruption or periosteal excavation on matched single HR-pQCT slices. On multiplane HR-pQCT images, 11 (21%) showed a cortical interruption in at least two consecutive slices in two planes, 36 (69%) in at least one slice in two planes and five (10%) showed no cortical interruption. Substantially more VCs were present in histology sections than initially suggested by HR-pQCT. The small size and heterogeneous presentation, limit the identification as VC on HR-pQCT.
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spelling pubmed-55669542017-08-23 Vascular channels in metacarpophalangeal joints: a comparative histologic and high-resolution imaging study Scharmga, A. Keller, K. K. Peters, M. van Tubergen, A. van den Bergh, J. P. van Rietbergen, B. Weijers, R. Loeffen, D. Hauge, E. M. Geusens, P. Sci Rep Article We evaluated whether cortical interruptions classified as vascular channel (VC) on high-resolution peripheral quantitative computed tomography (HR-pQCT) could be confirmed by histology. We subsequently evaluated the image characteristics of histologically identified VCs on matched single and multiplane HR-pQCT images. Four 3-mm thick portions in three anatomic metacarpophalangeal joint specimens were selected for histologic sectioning. First, VCs identified with HR-pQCT were examined for confirmation on histology. Second and independently, VCs identified by histology were matched to single and multiplane HR-pQCT images to assess for presence of cortical interruptions. Only one out of five cortical interruptions suggestive for VC on HR-pQCT could be confirmed on histology. In contrast, 52 VCs were identified by histology of which 39 (75%) could be classified as cortical interruption or periosteal excavation on matched single HR-pQCT slices. On multiplane HR-pQCT images, 11 (21%) showed a cortical interruption in at least two consecutive slices in two planes, 36 (69%) in at least one slice in two planes and five (10%) showed no cortical interruption. Substantially more VCs were present in histology sections than initially suggested by HR-pQCT. The small size and heterogeneous presentation, limit the identification as VC on HR-pQCT. Nature Publishing Group UK 2017-08-21 /pmc/articles/PMC5566954/ /pubmed/28827584 http://dx.doi.org/10.1038/s41598-017-09363-2 Text en © The Author(s) 2017 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Scharmga, A.
Keller, K. K.
Peters, M.
van Tubergen, A.
van den Bergh, J. P.
van Rietbergen, B.
Weijers, R.
Loeffen, D.
Hauge, E. M.
Geusens, P.
Vascular channels in metacarpophalangeal joints: a comparative histologic and high-resolution imaging study
title Vascular channels in metacarpophalangeal joints: a comparative histologic and high-resolution imaging study
title_full Vascular channels in metacarpophalangeal joints: a comparative histologic and high-resolution imaging study
title_fullStr Vascular channels in metacarpophalangeal joints: a comparative histologic and high-resolution imaging study
title_full_unstemmed Vascular channels in metacarpophalangeal joints: a comparative histologic and high-resolution imaging study
title_short Vascular channels in metacarpophalangeal joints: a comparative histologic and high-resolution imaging study
title_sort vascular channels in metacarpophalangeal joints: a comparative histologic and high-resolution imaging study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5566954/
https://www.ncbi.nlm.nih.gov/pubmed/28827584
http://dx.doi.org/10.1038/s41598-017-09363-2
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