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MEPicides: potent antimalarial prodrugs targeting isoprenoid biosynthesis

The emergence of Plasmodium falciparum resistant to frontline therapeutics has prompted efforts to identify and validate agents with novel mechanisms of action. MEPicides represent a new class of antimalarials that inhibit enzymes of the methylerythritol phosphate (MEP) pathway of isoprenoid biosynt...

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Detalles Bibliográficos
Autores principales:	Edwards, Rachel L., Brothers, Robert C., Wang, Xu, Maron, Maxim I., Ziniel, Peter D., Tsang, Patricia S., Kraft, Thomas E., Hruz, Paul W., Williamson, Kim C., Dowd, Cynthia S., John, Audrey R. Odom
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5567135/ https://www.ncbi.nlm.nih.gov/pubmed/28827774 http://dx.doi.org/10.1038/s41598-017-07159-y

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