The open architecture of HD-PTP phosphatase provides new insights into the mechanism of regulation of ESCRT function

HD-PTP is a tumour suppressor phosphatase that controls endocytosis, down-regulation of mitogenic receptors and cell migration. Central to its role is the specific recruitment of critical endosomal sorting complexes required for transport (ESCRTs). However, the molecular mechanisms that enable HD-PT...

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Detalles Bibliográficos
Autores principales: Gahloth, Deepankar, Heaven, Graham, Jowitt, Thomas A., Mould, A. Paul, Bella, Jordi, Baldock, Clair, Woodman, Philip, Tabernero, Lydia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5567221/
https://www.ncbi.nlm.nih.gov/pubmed/28831121
http://dx.doi.org/10.1038/s41598-017-09467-9

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