A miR-SNP biomarker linked to an increased lung cancer survival by miRNA-mediated down-regulation of FZD4 expression and Wnt signaling

Through a new hypothesis-driven and microRNA-pathway-based SNP (miR-SNP) association study we identified a novel miR-SNP (rs713065) in the 3′UTR region of FZD4 gene linked with decreased risk of death in early stage NSCLC patients. We determined biological function and mechanism of action of this FZ...

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Autores principales: Lin, Jing, Zandi, Roza, Shao, Ruping, Gu, Jian, Ye, Yuanqin, Wang, Jing, Zhao, Yang, Pertsemlidis, Alexander, Wistuba, Ignacio I., Wu, Xifeng, Roth, Jack A., Ji, Lin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
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Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5567228/
https://www.ncbi.nlm.nih.gov/pubmed/28831115
http://dx.doi.org/10.1038/s41598-017-09604-4
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author Lin, Jing
Zandi, Roza
Shao, Ruping
Gu, Jian
Ye, Yuanqin
Wang, Jing
Zhao, Yang
Pertsemlidis, Alexander
Wistuba, Ignacio I.
Wu, Xifeng
Roth, Jack A.
Ji, Lin
author_facet Lin, Jing
Zandi, Roza
Shao, Ruping
Gu, Jian
Ye, Yuanqin
Wang, Jing
Zhao, Yang
Pertsemlidis, Alexander
Wistuba, Ignacio I.
Wu, Xifeng
Roth, Jack A.
Ji, Lin
author_sort Lin, Jing
collection PubMed
description Through a new hypothesis-driven and microRNA-pathway-based SNP (miR-SNP) association study we identified a novel miR-SNP (rs713065) in the 3′UTR region of FZD4 gene linked with decreased risk of death in early stage NSCLC patients. We determined biological function and mechanism of action of this FZD4-miR-SNP biomarker in a cellular platform. Our data suggest that FZD4-miR-SNP loci may significantly influence overall survival in NSCLC patients by specifically interacting with miR-204 and modulating FZD4 expression and cellular function in the Wnt-signaling-driven tumor progression. Our findings are bridging the gap between the discovery of epidemiological SNP biomarkers and their biological function and will enable us to develop novel therapeutic strategies that specifically target epigenetic markers in the oncogenic Wnt/FZD signaling pathways in NSCLC.
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spelling pubmed-55672282017-09-01 A miR-SNP biomarker linked to an increased lung cancer survival by miRNA-mediated down-regulation of FZD4 expression and Wnt signaling Lin, Jing Zandi, Roza Shao, Ruping Gu, Jian Ye, Yuanqin Wang, Jing Zhao, Yang Pertsemlidis, Alexander Wistuba, Ignacio I. Wu, Xifeng Roth, Jack A. Ji, Lin Sci Rep Article Through a new hypothesis-driven and microRNA-pathway-based SNP (miR-SNP) association study we identified a novel miR-SNP (rs713065) in the 3′UTR region of FZD4 gene linked with decreased risk of death in early stage NSCLC patients. We determined biological function and mechanism of action of this FZD4-miR-SNP biomarker in a cellular platform. Our data suggest that FZD4-miR-SNP loci may significantly influence overall survival in NSCLC patients by specifically interacting with miR-204 and modulating FZD4 expression and cellular function in the Wnt-signaling-driven tumor progression. Our findings are bridging the gap between the discovery of epidemiological SNP biomarkers and their biological function and will enable us to develop novel therapeutic strategies that specifically target epigenetic markers in the oncogenic Wnt/FZD signaling pathways in NSCLC. Nature Publishing Group UK 2017-08-22 /pmc/articles/PMC5567228/ /pubmed/28831115 http://dx.doi.org/10.1038/s41598-017-09604-4 Text en © The Author(s) 2017 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Lin, Jing
Zandi, Roza
Shao, Ruping
Gu, Jian
Ye, Yuanqin
Wang, Jing
Zhao, Yang
Pertsemlidis, Alexander
Wistuba, Ignacio I.
Wu, Xifeng
Roth, Jack A.
Ji, Lin
A miR-SNP biomarker linked to an increased lung cancer survival by miRNA-mediated down-regulation of FZD4 expression and Wnt signaling
title A miR-SNP biomarker linked to an increased lung cancer survival by miRNA-mediated down-regulation of FZD4 expression and Wnt signaling
title_full A miR-SNP biomarker linked to an increased lung cancer survival by miRNA-mediated down-regulation of FZD4 expression and Wnt signaling
title_fullStr A miR-SNP biomarker linked to an increased lung cancer survival by miRNA-mediated down-regulation of FZD4 expression and Wnt signaling
title_full_unstemmed A miR-SNP biomarker linked to an increased lung cancer survival by miRNA-mediated down-regulation of FZD4 expression and Wnt signaling
title_short A miR-SNP biomarker linked to an increased lung cancer survival by miRNA-mediated down-regulation of FZD4 expression and Wnt signaling
title_sort mir-snp biomarker linked to an increased lung cancer survival by mirna-mediated down-regulation of fzd4 expression and wnt signaling
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5567228/
https://www.ncbi.nlm.nih.gov/pubmed/28831115
http://dx.doi.org/10.1038/s41598-017-09604-4
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