A miR-SNP biomarker linked to an increased lung cancer survival by miRNA-mediated down-regulation of FZD4 expression and Wnt signaling

Through a new hypothesis-driven and microRNA-pathway-based SNP (miR-SNP) association study we identified a novel miR-SNP (rs713065) in the 3′UTR region of FZD4 gene linked with decreased risk of death in early stage NSCLC patients. We determined biological function and mechanism of action of this FZ...

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Detalles Bibliográficos
Autores principales: Lin, Jing, Zandi, Roza, Shao, Ruping, Gu, Jian, Ye, Yuanqin, Wang, Jing, Zhao, Yang, Pertsemlidis, Alexander, Wistuba, Ignacio I., Wu, Xifeng, Roth, Jack A., Ji, Lin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5567228/
https://www.ncbi.nlm.nih.gov/pubmed/28831115
http://dx.doi.org/10.1038/s41598-017-09604-4

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