Inhibition of post-transcriptional steps in ribosome biogenesis confers cytoprotection against chemotherapeutic agents in a p53-dependent manner

The p53-mediated nucleolar stress response associated with inhibition of ribosomal RNA transcription was previously shown to potentiate killing of tumor cells. Here, we asked whether targeting of ribosome biogenesis can be used as the basis for selective p53-dependent cytoprotection of nonmalignant...

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Detalles Bibliográficos
Autores principales: Sapio, Russell T., Nezdyur, Anastasiya N., Krevetski, Matthew, Anikin, Leonid, Manna, Vincent J., Minkovsky, Natalie, Pestov, Dimitri G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5567254/
https://www.ncbi.nlm.nih.gov/pubmed/28831158
http://dx.doi.org/10.1038/s41598-017-09002-w

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