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Flow-induced elongation of von Willebrand factor precedes tension-dependent activation

Von Willebrand factor, an ultralarge concatemeric blood protein, must bind to platelet GPIbα during bleeding to mediate hemostasis, but not in the normal circulation to avoid thrombosis. Von Willebrand factor is proposed to be mechanically activated by flow, but the mechanism remains unclear. Using...

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Detalles Bibliográficos
Autores principales:	Fu, Hongxia, Jiang, Yan, Yang, Darren, Scheiflinger, Friedrich, Wong, Wesley P., Springer, Timothy A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5567343/ https://www.ncbi.nlm.nih.gov/pubmed/28831047 http://dx.doi.org/10.1038/s41467-017-00230-2

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