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Gastrointestinal adenocarcinoma metastasizing to the vulva: a case report

BACKGROUND: Metastatic vulval adenocarcinoma is a rare occurrence with only a few cases reported to date. They can arise from the breast, gastrointestinal system, or endometrium. CASE PRESENTATION: We present the case of a 55-year-old Black African woman who presented with vulval itching which progr...

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Autores principales: Gidiri, Muchabayiwa F., Nyakura, M., Hukuimwe, M., Magwali, T., Makunike-Mutasa, R., Museta, F. D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5567554/
https://www.ncbi.nlm.nih.gov/pubmed/28826403
http://dx.doi.org/10.1186/s13256-017-1399-8
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author Gidiri, Muchabayiwa F.
Nyakura, M.
Hukuimwe, M.
Magwali, T.
Makunike-Mutasa, R.
Museta, F. D.
author_facet Gidiri, Muchabayiwa F.
Nyakura, M.
Hukuimwe, M.
Magwali, T.
Makunike-Mutasa, R.
Museta, F. D.
author_sort Gidiri, Muchabayiwa F.
collection PubMed
description BACKGROUND: Metastatic vulval adenocarcinoma is a rare occurrence with only a few cases reported to date. They can arise from the breast, gastrointestinal system, or endometrium. CASE PRESENTATION: We present the case of a 55-year-old Black African woman who presented with vulval itching which progressed to warty lesions. Histology revealed a vulval adenocarcinoma which immunohistochemistry suggested was of gastrointestinal origin. Colonoscopy later confirmed an anorectal tumor as the primary site. Despite extensive chest metastases she looked surprisingly well and had no pulmonary symptoms. The major source of symptomatic distress was the itchy extensive warty lesions on her vulva. She has since had a vulvectomy which gave her significant symptomatic relief. CONCLUSIONS: This case was interesting as vulval adenocarcinoma is a rare histological diagnosis found in less than 10% of vulval cancers. Primary vulval adenocarcinoma is rare with most of these cancers being secondary metastases from a distant site. Her symptoms were predominantly vulval with no chest symptoms even though she had extensive pulmonary metastases. She has been clinically well except for the itching suggesting an indolent course.
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spelling pubmed-55675542017-08-29 Gastrointestinal adenocarcinoma metastasizing to the vulva: a case report Gidiri, Muchabayiwa F. Nyakura, M. Hukuimwe, M. Magwali, T. Makunike-Mutasa, R. Museta, F. D. J Med Case Rep Case Report BACKGROUND: Metastatic vulval adenocarcinoma is a rare occurrence with only a few cases reported to date. They can arise from the breast, gastrointestinal system, or endometrium. CASE PRESENTATION: We present the case of a 55-year-old Black African woman who presented with vulval itching which progressed to warty lesions. Histology revealed a vulval adenocarcinoma which immunohistochemistry suggested was of gastrointestinal origin. Colonoscopy later confirmed an anorectal tumor as the primary site. Despite extensive chest metastases she looked surprisingly well and had no pulmonary symptoms. The major source of symptomatic distress was the itchy extensive warty lesions on her vulva. She has since had a vulvectomy which gave her significant symptomatic relief. CONCLUSIONS: This case was interesting as vulval adenocarcinoma is a rare histological diagnosis found in less than 10% of vulval cancers. Primary vulval adenocarcinoma is rare with most of these cancers being secondary metastases from a distant site. Her symptoms were predominantly vulval with no chest symptoms even though she had extensive pulmonary metastases. She has been clinically well except for the itching suggesting an indolent course. BioMed Central 2017-08-22 /pmc/articles/PMC5567554/ /pubmed/28826403 http://dx.doi.org/10.1186/s13256-017-1399-8 Text en © The Author(s). 2017 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Case Report
Gidiri, Muchabayiwa F.
Nyakura, M.
Hukuimwe, M.
Magwali, T.
Makunike-Mutasa, R.
Museta, F. D.
Gastrointestinal adenocarcinoma metastasizing to the vulva: a case report
title Gastrointestinal adenocarcinoma metastasizing to the vulva: a case report
title_full Gastrointestinal adenocarcinoma metastasizing to the vulva: a case report
title_fullStr Gastrointestinal adenocarcinoma metastasizing to the vulva: a case report
title_full_unstemmed Gastrointestinal adenocarcinoma metastasizing to the vulva: a case report
title_short Gastrointestinal adenocarcinoma metastasizing to the vulva: a case report
title_sort gastrointestinal adenocarcinoma metastasizing to the vulva: a case report
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5567554/
https://www.ncbi.nlm.nih.gov/pubmed/28826403
http://dx.doi.org/10.1186/s13256-017-1399-8
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