The K(ATP) channel in migraine pathophysiology: a novel therapeutic target for migraine

BACKGROUND: To review the distribution and function of K(ATP) channels, describe the use of K(ATP) channels openers in clinical trials and make the case that these channels may play a role in headache and migraine. DISCUSSION: K(ATP) channels are widely present in the trigeminovascular system and pl...

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Detalles Bibliográficos
Autores principales: Al-Karagholi, Mohammad Al-Mahdi, Hansen, Jakob Møller, Severinsen, Johanne, Jansen-Olesen, Inger, Ashina, Messoud
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Milan 2017
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5567577/
https://www.ncbi.nlm.nih.gov/pubmed/28831746
http://dx.doi.org/10.1186/s10194-017-0800-8
Descripción
Sumario:BACKGROUND: To review the distribution and function of K(ATP) channels, describe the use of K(ATP) channels openers in clinical trials and make the case that these channels may play a role in headache and migraine. DISCUSSION: K(ATP) channels are widely present in the trigeminovascular system and play an important role in the regulation of tone in cerebral and meningeal arteries. Clinical trials using synthetic K(ATP) channel openers report headache as a prevalent-side effect in non-migraine sufferers, indicating that K(ATP) channel opening may cause headache, possibly due to vascular mechanisms. Whether K(ATP) channel openers can provoke migraine in migraine sufferers is not known. CONCLUSION: We suggest that K(ATP) channels may play an important role in migraine pathogenesis and could be a potential novel therapeutic anti-migraine target.

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