The K(ATP) channel in migraine pathophysiology: a novel therapeutic target for migraine

BACKGROUND: To review the distribution and function of K(ATP) channels, describe the use of K(ATP) channels openers in clinical trials and make the case that these channels may play a role in headache and migraine. DISCUSSION: K(ATP) channels are widely present in the trigeminovascular system and pl...

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Autores principales: Al-Karagholi, Mohammad Al-Mahdi, Hansen, Jakob Møller, Severinsen, Johanne, Jansen-Olesen, Inger, Ashina, Messoud
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Milan 2017
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5567577/
https://www.ncbi.nlm.nih.gov/pubmed/28831746
http://dx.doi.org/10.1186/s10194-017-0800-8
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author Al-Karagholi, Mohammad Al-Mahdi
Hansen, Jakob Møller
Severinsen, Johanne
Jansen-Olesen, Inger
Ashina, Messoud
author_facet Al-Karagholi, Mohammad Al-Mahdi
Hansen, Jakob Møller
Severinsen, Johanne
Jansen-Olesen, Inger
Ashina, Messoud
author_sort Al-Karagholi, Mohammad Al-Mahdi
collection PubMed
description BACKGROUND: To review the distribution and function of K(ATP) channels, describe the use of K(ATP) channels openers in clinical trials and make the case that these channels may play a role in headache and migraine. DISCUSSION: K(ATP) channels are widely present in the trigeminovascular system and play an important role in the regulation of tone in cerebral and meningeal arteries. Clinical trials using synthetic K(ATP) channel openers report headache as a prevalent-side effect in non-migraine sufferers, indicating that K(ATP) channel opening may cause headache, possibly due to vascular mechanisms. Whether K(ATP) channel openers can provoke migraine in migraine sufferers is not known. CONCLUSION: We suggest that K(ATP) channels may play an important role in migraine pathogenesis and could be a potential novel therapeutic anti-migraine target.
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spelling pubmed-55675772017-09-11 The K(ATP) channel in migraine pathophysiology: a novel therapeutic target for migraine Al-Karagholi, Mohammad Al-Mahdi Hansen, Jakob Møller Severinsen, Johanne Jansen-Olesen, Inger Ashina, Messoud J Headache Pain Review Article BACKGROUND: To review the distribution and function of K(ATP) channels, describe the use of K(ATP) channels openers in clinical trials and make the case that these channels may play a role in headache and migraine. DISCUSSION: K(ATP) channels are widely present in the trigeminovascular system and play an important role in the regulation of tone in cerebral and meningeal arteries. Clinical trials using synthetic K(ATP) channel openers report headache as a prevalent-side effect in non-migraine sufferers, indicating that K(ATP) channel opening may cause headache, possibly due to vascular mechanisms. Whether K(ATP) channel openers can provoke migraine in migraine sufferers is not known. CONCLUSION: We suggest that K(ATP) channels may play an important role in migraine pathogenesis and could be a potential novel therapeutic anti-migraine target. Springer Milan 2017-08-23 /pmc/articles/PMC5567577/ /pubmed/28831746 http://dx.doi.org/10.1186/s10194-017-0800-8 Text en © The Author(s). 2017 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Review Article
Al-Karagholi, Mohammad Al-Mahdi
Hansen, Jakob Møller
Severinsen, Johanne
Jansen-Olesen, Inger
Ashina, Messoud
The K(ATP) channel in migraine pathophysiology: a novel therapeutic target for migraine
title The K(ATP) channel in migraine pathophysiology: a novel therapeutic target for migraine
title_full The K(ATP) channel in migraine pathophysiology: a novel therapeutic target for migraine
title_fullStr The K(ATP) channel in migraine pathophysiology: a novel therapeutic target for migraine
title_full_unstemmed The K(ATP) channel in migraine pathophysiology: a novel therapeutic target for migraine
title_short The K(ATP) channel in migraine pathophysiology: a novel therapeutic target for migraine
title_sort k(atp) channel in migraine pathophysiology: a novel therapeutic target for migraine
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5567577/
https://www.ncbi.nlm.nih.gov/pubmed/28831746
http://dx.doi.org/10.1186/s10194-017-0800-8
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