Reversal of tenofovir induced nephrotoxicity: case reports of two patients

The use of the antiretroviral drug tenofovir has been associated with nephrotoxicity. However, the overall impact of this adverse effect has not comprehensively evaluated. Some researchers have reported that it is quite severe to warrant monitoring for renal toxicity, while others have concluded tha...

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Detalles Bibliográficos
Autores principales: Some, Fatuma, Koech, Mathew, Chesire, Emily, Kigen, Gabriel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The African Field Epidemiology Network 2017
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5567942/
https://www.ncbi.nlm.nih.gov/pubmed/28904656
http://dx.doi.org/10.11604/pamj.2017.27.126.10033
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author Some, Fatuma
Koech, Mathew
Chesire, Emily
Kigen, Gabriel
author_facet Some, Fatuma
Koech, Mathew
Chesire, Emily
Kigen, Gabriel
author_sort Some, Fatuma
collection PubMed
description The use of the antiretroviral drug tenofovir has been associated with nephrotoxicity. However, the overall impact of this adverse effect has not comprehensively evaluated. Some researchers have reported that it is quite severe to warrant monitoring for renal toxicity, while others have concluded that the magnitude may not be that significant. We report two clinical cases seen in our renal clinic with high creatinine levels suggestive of nephrotoxicity who reverted back to normality upon withdrawal of tenofovir.
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spelling pubmed-55679422017-09-13 Reversal of tenofovir induced nephrotoxicity: case reports of two patients Some, Fatuma Koech, Mathew Chesire, Emily Kigen, Gabriel Pan Afr Med J Case Report The use of the antiretroviral drug tenofovir has been associated with nephrotoxicity. However, the overall impact of this adverse effect has not comprehensively evaluated. Some researchers have reported that it is quite severe to warrant monitoring for renal toxicity, while others have concluded that the magnitude may not be that significant. We report two clinical cases seen in our renal clinic with high creatinine levels suggestive of nephrotoxicity who reverted back to normality upon withdrawal of tenofovir. The African Field Epidemiology Network 2017-06-16 /pmc/articles/PMC5567942/ /pubmed/28904656 http://dx.doi.org/10.11604/pamj.2017.27.126.10033 Text en © Fatuma Some et al. http://creativecommons.org/licenses/by/2.0/ The Pan African Medical Journal - ISSN 1937-8688. This is an Open Access article distributed under the terms of the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Some, Fatuma
Koech, Mathew
Chesire, Emily
Kigen, Gabriel
Reversal of tenofovir induced nephrotoxicity: case reports of two patients
title Reversal of tenofovir induced nephrotoxicity: case reports of two patients
title_full Reversal of tenofovir induced nephrotoxicity: case reports of two patients
title_fullStr Reversal of tenofovir induced nephrotoxicity: case reports of two patients
title_full_unstemmed Reversal of tenofovir induced nephrotoxicity: case reports of two patients
title_short Reversal of tenofovir induced nephrotoxicity: case reports of two patients
title_sort reversal of tenofovir induced nephrotoxicity: case reports of two patients
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5567942/
https://www.ncbi.nlm.nih.gov/pubmed/28904656
http://dx.doi.org/10.11604/pamj.2017.27.126.10033
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