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Evaluation of Placental mir-155-5p and Long Non-coding RNA sONE Expression in Patients with Severe Pre-eclampsia

It has been well documented that preeclampsia (PE) has a common etiological background, but little is known about its linkage at the molecular level.Non- coding RNAs are critical posttranscriptional regulators ofgene expression. This study was performed to determine whether PE is associated with alt...

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Autores principales: Azizi, Faezeh, Saleh Gargari, Soraya, Asadi Shahmirzadi, Sedigheh, Dodange, Fatemeh, Amiri, Vahid, Mirfakhraie, Reza, Omrani, Mir Davood
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Babol University of Medical Sciences 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5568189/
https://www.ncbi.nlm.nih.gov/pubmed/28868266
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author Azizi, Faezeh
Saleh Gargari, Soraya
Asadi Shahmirzadi, Sedigheh
Dodange, Fatemeh
Amiri, Vahid
Mirfakhraie, Reza
Omrani, Mir Davood
author_facet Azizi, Faezeh
Saleh Gargari, Soraya
Asadi Shahmirzadi, Sedigheh
Dodange, Fatemeh
Amiri, Vahid
Mirfakhraie, Reza
Omrani, Mir Davood
author_sort Azizi, Faezeh
collection PubMed
description It has been well documented that preeclampsia (PE) has a common etiological background, but little is known about its linkage at the molecular level.Non- coding RNAs are critical posttranscriptional regulators ofgene expression. This study was performed to determine whether PE is associated with alterations in placental non-coding RNAs expression. MicroRNA (miR)-155-5p and long non-coding RNA (lnc)sONE expression, in placentas collected sequentially from 59 patients with PE and 40 normotensive pregnancies were measured using real-time PCR.The relationship between miR-155-5p and lncsONE expressions was analyzed statistically. miR-155-5p expression was increased (fold change =1.6, P=0.04), while lncsONE expression was not significantly changed (fold change =1.1, P=0.68), in placentas from patients compared with control group.miR-155-5p was upregulated in placentas from patients with PE and may have influenced eNOS expression. These findings indicate that miRNA-155-5p may be involved in PE pathogenesis and could be a potential biomarker for this disease.
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spelling pubmed-55681892017-09-01 Evaluation of Placental mir-155-5p and Long Non-coding RNA sONE Expression in Patients with Severe Pre-eclampsia Azizi, Faezeh Saleh Gargari, Soraya Asadi Shahmirzadi, Sedigheh Dodange, Fatemeh Amiri, Vahid Mirfakhraie, Reza Omrani, Mir Davood Int J Mol Cell Med Original Article It has been well documented that preeclampsia (PE) has a common etiological background, but little is known about its linkage at the molecular level.Non- coding RNAs are critical posttranscriptional regulators ofgene expression. This study was performed to determine whether PE is associated with alterations in placental non-coding RNAs expression. MicroRNA (miR)-155-5p and long non-coding RNA (lnc)sONE expression, in placentas collected sequentially from 59 patients with PE and 40 normotensive pregnancies were measured using real-time PCR.The relationship between miR-155-5p and lncsONE expressions was analyzed statistically. miR-155-5p expression was increased (fold change =1.6, P=0.04), while lncsONE expression was not significantly changed (fold change =1.1, P=0.68), in placentas from patients compared with control group.miR-155-5p was upregulated in placentas from patients with PE and may have influenced eNOS expression. These findings indicate that miRNA-155-5p may be involved in PE pathogenesis and could be a potential biomarker for this disease. Babol University of Medical Sciences 2017 2017-01-17 /pmc/articles/PMC5568189/ /pubmed/28868266 Text en This is an Open Access article distributed under the terms of the Creative Commons Attribution License, (http://creativecommons.org/licenses/by/3.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Azizi, Faezeh
Saleh Gargari, Soraya
Asadi Shahmirzadi, Sedigheh
Dodange, Fatemeh
Amiri, Vahid
Mirfakhraie, Reza
Omrani, Mir Davood
Evaluation of Placental mir-155-5p and Long Non-coding RNA sONE Expression in Patients with Severe Pre-eclampsia
title Evaluation of Placental mir-155-5p and Long Non-coding RNA sONE Expression in Patients with Severe Pre-eclampsia
title_full Evaluation of Placental mir-155-5p and Long Non-coding RNA sONE Expression in Patients with Severe Pre-eclampsia
title_fullStr Evaluation of Placental mir-155-5p and Long Non-coding RNA sONE Expression in Patients with Severe Pre-eclampsia
title_full_unstemmed Evaluation of Placental mir-155-5p and Long Non-coding RNA sONE Expression in Patients with Severe Pre-eclampsia
title_short Evaluation of Placental mir-155-5p and Long Non-coding RNA sONE Expression in Patients with Severe Pre-eclampsia
title_sort evaluation of placental mir-155-5p and long non-coding rna sone expression in patients with severe pre-eclampsia
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5568189/
https://www.ncbi.nlm.nih.gov/pubmed/28868266
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