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Evaluation of Placental mir-155-5p and Long Non-coding RNA sONE Expression in Patients with Severe Pre-eclampsia
It has been well documented that preeclampsia (PE) has a common etiological background, but little is known about its linkage at the molecular level.Non- coding RNAs are critical posttranscriptional regulators ofgene expression. This study was performed to determine whether PE is associated with alt...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Babol University of Medical Sciences
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5568189/ https://www.ncbi.nlm.nih.gov/pubmed/28868266 |
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author | Azizi, Faezeh Saleh Gargari, Soraya Asadi Shahmirzadi, Sedigheh Dodange, Fatemeh Amiri, Vahid Mirfakhraie, Reza Omrani, Mir Davood |
author_facet | Azizi, Faezeh Saleh Gargari, Soraya Asadi Shahmirzadi, Sedigheh Dodange, Fatemeh Amiri, Vahid Mirfakhraie, Reza Omrani, Mir Davood |
author_sort | Azizi, Faezeh |
collection | PubMed |
description | It has been well documented that preeclampsia (PE) has a common etiological background, but little is known about its linkage at the molecular level.Non- coding RNAs are critical posttranscriptional regulators ofgene expression. This study was performed to determine whether PE is associated with alterations in placental non-coding RNAs expression. MicroRNA (miR)-155-5p and long non-coding RNA (lnc)sONE expression, in placentas collected sequentially from 59 patients with PE and 40 normotensive pregnancies were measured using real-time PCR.The relationship between miR-155-5p and lncsONE expressions was analyzed statistically. miR-155-5p expression was increased (fold change =1.6, P=0.04), while lncsONE expression was not significantly changed (fold change =1.1, P=0.68), in placentas from patients compared with control group.miR-155-5p was upregulated in placentas from patients with PE and may have influenced eNOS expression. These findings indicate that miRNA-155-5p may be involved in PE pathogenesis and could be a potential biomarker for this disease. |
format | Online Article Text |
id | pubmed-5568189 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Babol University of Medical Sciences |
record_format | MEDLINE/PubMed |
spelling | pubmed-55681892017-09-01 Evaluation of Placental mir-155-5p and Long Non-coding RNA sONE Expression in Patients with Severe Pre-eclampsia Azizi, Faezeh Saleh Gargari, Soraya Asadi Shahmirzadi, Sedigheh Dodange, Fatemeh Amiri, Vahid Mirfakhraie, Reza Omrani, Mir Davood Int J Mol Cell Med Original Article It has been well documented that preeclampsia (PE) has a common etiological background, but little is known about its linkage at the molecular level.Non- coding RNAs are critical posttranscriptional regulators ofgene expression. This study was performed to determine whether PE is associated with alterations in placental non-coding RNAs expression. MicroRNA (miR)-155-5p and long non-coding RNA (lnc)sONE expression, in placentas collected sequentially from 59 patients with PE and 40 normotensive pregnancies were measured using real-time PCR.The relationship between miR-155-5p and lncsONE expressions was analyzed statistically. miR-155-5p expression was increased (fold change =1.6, P=0.04), while lncsONE expression was not significantly changed (fold change =1.1, P=0.68), in placentas from patients compared with control group.miR-155-5p was upregulated in placentas from patients with PE and may have influenced eNOS expression. These findings indicate that miRNA-155-5p may be involved in PE pathogenesis and could be a potential biomarker for this disease. Babol University of Medical Sciences 2017 2017-01-17 /pmc/articles/PMC5568189/ /pubmed/28868266 Text en This is an Open Access article distributed under the terms of the Creative Commons Attribution License, (http://creativecommons.org/licenses/by/3.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Azizi, Faezeh Saleh Gargari, Soraya Asadi Shahmirzadi, Sedigheh Dodange, Fatemeh Amiri, Vahid Mirfakhraie, Reza Omrani, Mir Davood Evaluation of Placental mir-155-5p and Long Non-coding RNA sONE Expression in Patients with Severe Pre-eclampsia |
title | Evaluation of Placental mir-155-5p and Long Non-coding RNA sONE Expression in Patients with Severe Pre-eclampsia |
title_full | Evaluation of Placental mir-155-5p and Long Non-coding RNA sONE Expression in Patients with Severe Pre-eclampsia |
title_fullStr | Evaluation of Placental mir-155-5p and Long Non-coding RNA sONE Expression in Patients with Severe Pre-eclampsia |
title_full_unstemmed | Evaluation of Placental mir-155-5p and Long Non-coding RNA sONE Expression in Patients with Severe Pre-eclampsia |
title_short | Evaluation of Placental mir-155-5p and Long Non-coding RNA sONE Expression in Patients with Severe Pre-eclampsia |
title_sort | evaluation of placental mir-155-5p and long non-coding rna sone expression in patients with severe pre-eclampsia |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5568189/ https://www.ncbi.nlm.nih.gov/pubmed/28868266 |
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