Rapid evolution of the PB1-F2 virulence protein expressed by human seasonal H3N2 influenza viruses reduces inflammatory responses to infection

Influenza A virus (IAV) PB1-F2 protein has been linked to viral virulence. Strains of the H3N2 subtype historically express full-length PB1-F2 proteins but during the 2010–2011 influenza seasons, nearly half of the circulating H3N2 IAVs encoded truncated PB1-F2 protein. Using a panel of reverse engi...

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Detalles Bibliográficos
Autores principales: McAuley, Julie, Deng, Yi-Mo, Gilbertson, Brad, Mackenzie-Kludas, Charley, Barr, Ian, Brown, Lorena
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Short Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5568198/
https://www.ncbi.nlm.nih.gov/pubmed/28830486
http://dx.doi.org/10.1186/s12985-017-0827-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5568198/
https://www.ncbi.nlm.nih.gov/pubmed/28830486
http://dx.doi.org/10.1186/s12985-017-0827-0

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