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IL-18 associated with lung lymphoid aggregates drives IFNγ production in severe COPD

BACKGROUND: Increased interferon gamma (IFNγ) release occurs in Chronic Obstructive Pulmonary Disease (COPD) lungs. IFNγ supports optimal viral clearance, but if dysregulated could increase lung tissue destruction. METHODS: The present study investigates which mediators most closely correlate with I...

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Detalles Bibliográficos
Autores principales:	Briend, Emmanuel, Ferguson, G. John, Mori, Michiko, Damera, Gautam, Stephenson, Katherine, Karp, Natasha A., Sethi, Sanjay, Ward, Christine K., Sleeman, Matthew A., Erjefält, Jonas S., Finch, Donna K.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2017
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5568255/ https://www.ncbi.nlm.nih.gov/pubmed/28830544 http://dx.doi.org/10.1186/s12931-017-0641-7

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