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DNA strand breaks and TDP-43 mislocation are absent in the murine hSOD1(G93A) model of amyotrophic lateral sclerosis in vivo and in vitro

Mutations in the human Cu/Zn superoxide dismutase type-1 (hSOD1) gene are common in familial amyotrophic lateral sclerosis (fALS). The pathophysiology has been linked to, e.g., organelle dysfunction, RNA metabolism and oxidative DNA damage conferred by SOD1 malfunction. However, apart from metabolic...

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Detalles Bibliográficos
Autores principales:	Penndorf, Diane, Tadić, Vedrana, Witte, Otto W., Grosskreutz, Julian, Kretz, Alexandra
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2017
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5568271/ https://www.ncbi.nlm.nih.gov/pubmed/28832631 http://dx.doi.org/10.1371/journal.pone.0183684

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