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Relationship between GNAS1 T393C polymorphism and aseptic loosening after total hip arthroplasty
BACKGROUND: Aseptic loosening is a main cause for revision surgery after total hip arthroplasty (THA) and there is no reliable marker for the early detection of patients at high risk. This study has been performed to validate association of the T393C polymorphism (rs7121) in the GNAS1 gene, encoding...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5568317/ https://www.ncbi.nlm.nih.gov/pubmed/28830502 http://dx.doi.org/10.1186/s40001-017-0271-z |
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author | Stelmach, Patrick Kauther, Max D. Fuest, Lena Kurscheid, Gina Gehrke, Thorsten Klenke, Stefanie Jäger, Marcus Wedemeyer, Christian Bachmann, Hagen S. |
author_facet | Stelmach, Patrick Kauther, Max D. Fuest, Lena Kurscheid, Gina Gehrke, Thorsten Klenke, Stefanie Jäger, Marcus Wedemeyer, Christian Bachmann, Hagen S. |
author_sort | Stelmach, Patrick |
collection | PubMed |
description | BACKGROUND: Aseptic loosening is a main cause for revision surgery after total hip arthroplasty (THA) and there is no reliable marker for the early detection of patients at high risk. This study has been performed to validate association of the T393C polymorphism (rs7121) in the GNAS1 gene, encoding for the alpha-subunit of heterotrimeric G-protein Gs, with risk for and time to aseptic loosening after THA, which has been demonstrated in our previous study. METHODS: 231 patients with primary THA and 234 patients suffering from aseptic loosening were genotyped for dependency on GNAS1 genotypes and analyzed. RESULTS: Genotyping revealed almost similar minor allele frequencies of 0.49 and 0.46, respectively. Consistently, genotype distributions of both groups were not significantly different (p = 0.572). Neither gender nor GNAS1 genotype showed a statistically significant association with time to loosening (p = 0.501 and p = 0.840). Stratification by gender, as performed in our previous study, was not able to show a significant genotype-dependent difference in time (female p = 0.313; male p = 0.584) as well as median time to aseptic loosening (female p = 0.353; male p = 0.868). CONCLUSION: This study was not able to confirm the results of our preliminary study. An association of the GNAS1 T393C polymorphisms with risk for and time to aseptic loosening after THA is unlikely. |
format | Online Article Text |
id | pubmed-5568317 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-55683172017-08-29 Relationship between GNAS1 T393C polymorphism and aseptic loosening after total hip arthroplasty Stelmach, Patrick Kauther, Max D. Fuest, Lena Kurscheid, Gina Gehrke, Thorsten Klenke, Stefanie Jäger, Marcus Wedemeyer, Christian Bachmann, Hagen S. Eur J Med Res Research BACKGROUND: Aseptic loosening is a main cause for revision surgery after total hip arthroplasty (THA) and there is no reliable marker for the early detection of patients at high risk. This study has been performed to validate association of the T393C polymorphism (rs7121) in the GNAS1 gene, encoding for the alpha-subunit of heterotrimeric G-protein Gs, with risk for and time to aseptic loosening after THA, which has been demonstrated in our previous study. METHODS: 231 patients with primary THA and 234 patients suffering from aseptic loosening were genotyped for dependency on GNAS1 genotypes and analyzed. RESULTS: Genotyping revealed almost similar minor allele frequencies of 0.49 and 0.46, respectively. Consistently, genotype distributions of both groups were not significantly different (p = 0.572). Neither gender nor GNAS1 genotype showed a statistically significant association with time to loosening (p = 0.501 and p = 0.840). Stratification by gender, as performed in our previous study, was not able to show a significant genotype-dependent difference in time (female p = 0.313; male p = 0.584) as well as median time to aseptic loosening (female p = 0.353; male p = 0.868). CONCLUSION: This study was not able to confirm the results of our preliminary study. An association of the GNAS1 T393C polymorphisms with risk for and time to aseptic loosening after THA is unlikely. BioMed Central 2017-08-23 /pmc/articles/PMC5568317/ /pubmed/28830502 http://dx.doi.org/10.1186/s40001-017-0271-z Text en © The Author(s) 2017 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Research Stelmach, Patrick Kauther, Max D. Fuest, Lena Kurscheid, Gina Gehrke, Thorsten Klenke, Stefanie Jäger, Marcus Wedemeyer, Christian Bachmann, Hagen S. Relationship between GNAS1 T393C polymorphism and aseptic loosening after total hip arthroplasty |
title | Relationship between GNAS1 T393C polymorphism and aseptic loosening after total hip arthroplasty |
title_full | Relationship between GNAS1 T393C polymorphism and aseptic loosening after total hip arthroplasty |
title_fullStr | Relationship between GNAS1 T393C polymorphism and aseptic loosening after total hip arthroplasty |
title_full_unstemmed | Relationship between GNAS1 T393C polymorphism and aseptic loosening after total hip arthroplasty |
title_short | Relationship between GNAS1 T393C polymorphism and aseptic loosening after total hip arthroplasty |
title_sort | relationship between gnas1 t393c polymorphism and aseptic loosening after total hip arthroplasty |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5568317/ https://www.ncbi.nlm.nih.gov/pubmed/28830502 http://dx.doi.org/10.1186/s40001-017-0271-z |
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