3-O-trans-p-coumaroyl-alphitolic acid, a triterpenoid from Zizyphus jujuba, leads to apoptotic cell death in human leukemia cells through reactive oxygen species production and activation of the unfolded protein response

3-O-trans-p-coumaroyl-alphitolic acid (3OTPCA), a triterpenoid isolated from the plant Zizyphus jujuba (ZJ), is known to be cytotoxic to cancer cells; however, the molecular mechanism underlying 3OTPCA-induced cell death remains unknown. Here, we provide novel evidence that 3OTPCA induces apoptotic...

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Detalles Bibliográficos
Autores principales: Mitsuhashi, Yohei, Furusawa, Yukihiro, Aradate, Tadashi, Zhao, Qing-Li, Moniruzzaman, Rohan, Kanamori, Masahiko, Noguchi, Kyo, Kondo, Takashi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5568338/
https://www.ncbi.nlm.nih.gov/pubmed/28832644
http://dx.doi.org/10.1371/journal.pone.0183712

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