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Distinct aging profiles of CD8(+) T cells in blood versus gastrointestinal mucosal compartments
A hallmark of human immunosenescence is the accumulation of late-differentiated memory CD8(+) T cells with features of replicative senescence, such as inability to proliferate, absence of CD28 expression, shortened telomeres, loss of telomerase activity, enhanced activation, and increased secretion...
| Autores principales: | , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2017
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5568404/ https://www.ncbi.nlm.nih.gov/pubmed/28832609 http://dx.doi.org/10.1371/journal.pone.0182498 |