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Molecular response to imatinib mesylate of Brazilian patients with chronic myeloid leukemia

BACKGROUND: Imatinib mesylate has revolutionized the treatment of chronic myeloid leukemia leading to significant reductions of BCR-ABL1 transcript levels in peripheral blood. OBJECTIVE: To evaluate the response to imatinib mesylate treatment (400 mg/day) in Brazilian patients in the chronic phase o...

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Detalles Bibliográficos
Autores principales: Vieira-Mion, Ana Lucia, Pereira, Noemi Farah, Funke, Vaneuza Araujo Moreira, Pasquini, Ricardo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Sociedade Brasileira de Hematologia e Hemoterapia 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5568590/
https://www.ncbi.nlm.nih.gov/pubmed/28830599
http://dx.doi.org/10.1016/j.bjhh.2017.04.007
Descripción
Sumario:BACKGROUND: Imatinib mesylate has revolutionized the treatment of chronic myeloid leukemia leading to significant reductions of BCR-ABL1 transcript levels in peripheral blood. OBJECTIVE: To evaluate the response to imatinib mesylate treatment (400 mg/day) in Brazilian patients in the chronic phase of chronic myeloid leukemia monitored by quantitative real time polymerase chain reaction. METHODS: Between October 2002 and October 2010, 3169 peripheral blood samples were collected from 1403 patients from 3 to 5 months, 6 to 11 months, 12 to 17 months, 18 to 23 months and ≥24 months after beginning imatinib treatment. Eighty-two patients had samples available and analyzed for all time intervals. BCR-ABL1 quantification was performed by quantitative real time polymerase chain reaction using the ABL1 gene as the control. Results of the BCR-ABL1 ratio as a percentage were reported by the international scale (IS) using the laboratory conversion factor (0.51). RESULTS: In the first interval, 80.8% of patients achieved the optimal response (BCR-ABL1(IS) ≤ 10%). In the second period, 69.1% achieved optimal response (BCR-ABL1(IS) ≤ 1%) and, between 12 and 17 months, 47.3% achieved major molecular response (BCR-ABL1(IS) ≤ 0.1%). CONCLUSIONS: The results of this retrospective study show that the response to imatinib treatment (400 mg/day) of Brazilian patients in the chronic phase of chronic myeloid leukemia is within the expected profile when compared to patients reported in international prospective randomized studies.