The scaffold protein Ajuba suppresses CdGAP activity in epithelia to maintain stable cell-cell contacts

Levels of active Rac1 at epithelial junctions are partially modulated via interaction with Ajuba, an actin binding and scaffolding protein. Here we demonstrate that Ajuba interacts with the Cdc42 GTPase activating protein CdGAP, a GAP for Rac1 and Cdc42, at cell-cell contacts. CdGAP recruitment to j...

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Detalles Bibliográficos
Autores principales: McCormack, J. J., Bruche, S., Ouadda, A. B. D., Ishii, H., Lu, H., Garcia-Cattaneo, A., Chávez-Olórtegui, C., Lamarche-Vane, N., Braga, V. M. M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5569031/
https://www.ncbi.nlm.nih.gov/pubmed/28835688
http://dx.doi.org/10.1038/s41598-017-09024-4

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