Dengue-associated hemophagocyticlymphohistiocytosis in an adult: A case report and literature review

BACKGROUND: Infection-associated hemophagocytic syndrome (IAHS) is potentially a fatal disease caused by systemic infection complicated by hemophagocyticlymphohistiocytosis (HLH). Here, we report a case of HLH associated with dengue hemorrhagic fever (DHF) after a trip to Thailand. CASE SUMMARY: A 3...

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Detalles Bibliográficos
Autores principales: Chung, Sang Mi, Song, Joon Young, Kim, Wonshik, Choi, Min Joo, Jeon, Ji Ho, Kang, Seonghui, Jung, Eunju, Noh, Ji Yun, Cheong, Hee Jin, Kim, Woo Joo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer Health 2017
Materias:
4900
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5569431/
https://www.ncbi.nlm.nih.gov/pubmed/28225498
http://dx.doi.org/10.1097/MD.0000000000006159
Descripción
Sumario:BACKGROUND: Infection-associated hemophagocytic syndrome (IAHS) is potentially a fatal disease caused by systemic infection complicated by hemophagocyticlymphohistiocytosis (HLH). Here, we report a case of HLH associated with dengue hemorrhagic fever (DHF) after a trip to Thailand. CASE SUMMARY: A 33-year-old healthy female patient presented with 3 days of fever, myalgia, and skin rash. Serotype 3 dengue virus was isolated. Clinical and laboratory findings fulfilled the criteria of HLH. After the initiation of corticosteroid therapy, the patient recovered and laboratory findings were normalized. CONCLUSION: It would be important to differentially diagnose dengue-associated HLH from severe DHF. Early recognition and initiation of steroid treatment would be crucial for the successful treatment of dengue fever complicated by HLH.

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