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Aβ accumulation causes MVB enlargement and is modelled by dominant negative VPS4A

BACKGROUND: Alzheimer’s disease (AD)-linked β-amyloid (Aβ) accumulates in multivesicular bodies (MVBs) with the onset of AD pathogenesis. Alterations in endosomes are among the earliest changes associated with AD but the mechanism(s) that cause endosome enlargement and the effects of MVB dysfunction...

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Detalles Bibliográficos
Autores principales:	Willén, Katarina, Edgar, James R., Hasegawa, Takafumi, Tanaka, Nobuyuki, Futter, Clare E., Gouras, Gunnar K.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2017
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5569475/ https://www.ncbi.nlm.nih.gov/pubmed/28835279 http://dx.doi.org/10.1186/s13024-017-0203-y

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