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The Protective Effects of Fasciotomy on Reperfusion Injury of Skeletal Muscle of Rabbits
The authors aim to investigate protective effects of fasciotomy against ischemia reperfusion injury of skeletal muscle in rabbit and to compare the treatment effects of prereperfusion + fasciotomy and fasciotomy + postreperfusion against ischemia reperfusion injury of skeletal muscle. 24 healthy mal...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5569626/ https://www.ncbi.nlm.nih.gov/pubmed/28856161 http://dx.doi.org/10.1155/2017/7238960 |
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author | Li, Rui-Hua Li, Jin Kan, Shi-Lian Zhang, Xi-Nan |
author_facet | Li, Rui-Hua Li, Jin Kan, Shi-Lian Zhang, Xi-Nan |
author_sort | Li, Rui-Hua |
collection | PubMed |
description | The authors aim to investigate protective effects of fasciotomy against ischemia reperfusion injury of skeletal muscle in rabbit and to compare the treatment effects of prereperfusion + fasciotomy and fasciotomy + postreperfusion against ischemia reperfusion injury of skeletal muscle. 24 healthy male Japanese white rabbits were randomly divided into 3 groups, and 4 hours' ischemia was established in these rabbits through surgery. Six hours' reperfusion was performed in group A; reperfusion + postfasciotomy was performed in group B; and prefasciotomy + reperfusion was performed in group C. Result showed that prefasciotomy and postfasciotomy could protect skeletal muscle against ischemia reperfusion injury, reduced MDA (malondialdehyde) expression, MPO (myeloperoxidase) expression, and apoptosis of muscle in the reperfused areas, increased Bcl-2 expression, and decreased Bax expression. The MDA and MPO levels in group B and group C were significantly lower than those in group A, and MDA and MPO levels in group C were significantly lower than those in group B. Prefasciotomy and postfasciotomy could protect against ischemia reperfusion injury in skeletal muscle. The protective effects of prefasciotomy against ischemia reperfusion injury are better than postfasciotomy. |
format | Online Article Text |
id | pubmed-5569626 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-55696262017-08-30 The Protective Effects of Fasciotomy on Reperfusion Injury of Skeletal Muscle of Rabbits Li, Rui-Hua Li, Jin Kan, Shi-Lian Zhang, Xi-Nan Biomed Res Int Research Article The authors aim to investigate protective effects of fasciotomy against ischemia reperfusion injury of skeletal muscle in rabbit and to compare the treatment effects of prereperfusion + fasciotomy and fasciotomy + postreperfusion against ischemia reperfusion injury of skeletal muscle. 24 healthy male Japanese white rabbits were randomly divided into 3 groups, and 4 hours' ischemia was established in these rabbits through surgery. Six hours' reperfusion was performed in group A; reperfusion + postfasciotomy was performed in group B; and prefasciotomy + reperfusion was performed in group C. Result showed that prefasciotomy and postfasciotomy could protect skeletal muscle against ischemia reperfusion injury, reduced MDA (malondialdehyde) expression, MPO (myeloperoxidase) expression, and apoptosis of muscle in the reperfused areas, increased Bcl-2 expression, and decreased Bax expression. The MDA and MPO levels in group B and group C were significantly lower than those in group A, and MDA and MPO levels in group C were significantly lower than those in group B. Prefasciotomy and postfasciotomy could protect against ischemia reperfusion injury in skeletal muscle. The protective effects of prefasciotomy against ischemia reperfusion injury are better than postfasciotomy. Hindawi 2017 2017-08-10 /pmc/articles/PMC5569626/ /pubmed/28856161 http://dx.doi.org/10.1155/2017/7238960 Text en Copyright © 2017 Rui-Hua Li et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Li, Rui-Hua Li, Jin Kan, Shi-Lian Zhang, Xi-Nan The Protective Effects of Fasciotomy on Reperfusion Injury of Skeletal Muscle of Rabbits |
title | The Protective Effects of Fasciotomy on Reperfusion Injury of Skeletal Muscle of Rabbits |
title_full | The Protective Effects of Fasciotomy on Reperfusion Injury of Skeletal Muscle of Rabbits |
title_fullStr | The Protective Effects of Fasciotomy on Reperfusion Injury of Skeletal Muscle of Rabbits |
title_full_unstemmed | The Protective Effects of Fasciotomy on Reperfusion Injury of Skeletal Muscle of Rabbits |
title_short | The Protective Effects of Fasciotomy on Reperfusion Injury of Skeletal Muscle of Rabbits |
title_sort | protective effects of fasciotomy on reperfusion injury of skeletal muscle of rabbits |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5569626/ https://www.ncbi.nlm.nih.gov/pubmed/28856161 http://dx.doi.org/10.1155/2017/7238960 |
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