An unusual neck tumor in a young pregnant woman: challenge diagnosis and response to treatment

We report the case of a 19-year-old woman 33 weeks pregnant who presented a painful mass of progressive growth in the neck, having also dysphonia and dyspnea. Physical examination revealed a primary laryngeal tumor. A neuroendocrine small-cell carcinoma was diagnosed after histopathology, immunohist...

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Autores principales: Arango, Juan F., López, Juan C., Arrazubi, Virginia, Cisneros, Silvia, Rodríguez, Angel, Zabala, Aitor, Martinez del Prado, Purificación
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2017
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5569942/
https://www.ncbi.nlm.nih.gov/pubmed/28852532
http://dx.doi.org/10.1093/omcr/omx039
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author Arango, Juan F.
López, Juan C.
Arrazubi, Virginia
Cisneros, Silvia
Rodríguez, Angel
Zabala, Aitor
Martinez del Prado, Purificación
author_facet Arango, Juan F.
López, Juan C.
Arrazubi, Virginia
Cisneros, Silvia
Rodríguez, Angel
Zabala, Aitor
Martinez del Prado, Purificación
author_sort Arango, Juan F.
collection PubMed
description We report the case of a 19-year-old woman 33 weeks pregnant who presented a painful mass of progressive growth in the neck, having also dysphonia and dyspnea. Physical examination revealed a primary laryngeal tumor. A neuroendocrine small-cell carcinoma was diagnosed after histopathology, immunohistochemistry and genetic studies. Chemo-radiotherapy with a cisplatin-etoposide schedule was administered. Despite obtaining a complete response, the patient relapsed and finally survived 35 months with successive cisplatin-based treatments. Small-cell neuroendocrine carcinoma of the larynx is an uncommon entity, differential diagnosis can be problematic and treatment is challenging.
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spelling pubmed-55699422017-08-29 An unusual neck tumor in a young pregnant woman: challenge diagnosis and response to treatment Arango, Juan F. López, Juan C. Arrazubi, Virginia Cisneros, Silvia Rodríguez, Angel Zabala, Aitor Martinez del Prado, Purificación Oxf Med Case Reports Case Report We report the case of a 19-year-old woman 33 weeks pregnant who presented a painful mass of progressive growth in the neck, having also dysphonia and dyspnea. Physical examination revealed a primary laryngeal tumor. A neuroendocrine small-cell carcinoma was diagnosed after histopathology, immunohistochemistry and genetic studies. Chemo-radiotherapy with a cisplatin-etoposide schedule was administered. Despite obtaining a complete response, the patient relapsed and finally survived 35 months with successive cisplatin-based treatments. Small-cell neuroendocrine carcinoma of the larynx is an uncommon entity, differential diagnosis can be problematic and treatment is challenging. Oxford University Press 2017-08-02 /pmc/articles/PMC5569942/ /pubmed/28852532 http://dx.doi.org/10.1093/omcr/omx039 Text en © The Author 2017. Published by Oxford University Press. http://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle Case Report
Arango, Juan F.
López, Juan C.
Arrazubi, Virginia
Cisneros, Silvia
Rodríguez, Angel
Zabala, Aitor
Martinez del Prado, Purificación
An unusual neck tumor in a young pregnant woman: challenge diagnosis and response to treatment
title An unusual neck tumor in a young pregnant woman: challenge diagnosis and response to treatment
title_full An unusual neck tumor in a young pregnant woman: challenge diagnosis and response to treatment
title_fullStr An unusual neck tumor in a young pregnant woman: challenge diagnosis and response to treatment
title_full_unstemmed An unusual neck tumor in a young pregnant woman: challenge diagnosis and response to treatment
title_short An unusual neck tumor in a young pregnant woman: challenge diagnosis and response to treatment
title_sort unusual neck tumor in a young pregnant woman: challenge diagnosis and response to treatment
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5569942/
https://www.ncbi.nlm.nih.gov/pubmed/28852532
http://dx.doi.org/10.1093/omcr/omx039
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