The contribution of homology arms to nuclease-assisted genome engineering

Designer nucleases like CRISPR/Cas9 enable fluent site-directed damage or small mutations in many genomes. Strategies for their use to achieve more complex tasks like regional exchanges for gene humanization or the establishment of conditional alleles are still emerging. To optimize Cas9-assisted ta...

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Detalles Bibliográficos
Autores principales: Baker, Oliver, Tsurkan, Sarah, Fu, Jun, Klink, Barbara, Rump, Andreas, Obst, Mandy, Kranz, Andrea, Schröck, Evelin, Anastassiadis, Konstantinos, Stewart, A. Francis
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2017
Materias:
Synthetic Biology and Bioengineering
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5570031/
https://www.ncbi.nlm.nih.gov/pubmed/28582546
http://dx.doi.org/10.1093/nar/gkx497

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5570031/
https://www.ncbi.nlm.nih.gov/pubmed/28582546
http://dx.doi.org/10.1093/nar/gkx497

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