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Phosphorylated SIRT1 associates with replication origins to prevent excess replication initiation and preserve genomic stability

Chromatin structure affects DNA replication patterns, but the role of specific chromatin modifiers in regulating the replication process is yet unclear. We report that phosphorylation of the human SIRT1 deacetylase on Threonine 530 (T530-pSIRT1) modulates DNA synthesis. T530-pSIRT1 associates with r...

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Detalles Bibliográficos
Autores principales: Utani, Koichi, Fu, Haiqing, Jang, Sang-Min, Marks, Anna B., Smith, Owen K., Zhang, Ya, Redon, Christophe E., Shimizu, Noriaki, Aladjem, Mirit I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5570034/
https://www.ncbi.nlm.nih.gov/pubmed/28549174
http://dx.doi.org/10.1093/nar/gkx468

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