Major hnRNP proteins act as general TDP-43 functional modifiers both in Drosophila and human neuronal cells

Nuclear factor TDP-43 is known to play an important role in several neurodegenerative pathologies. In general, TDP-43 is an abundant protein within the eukaryotic nucleus that binds to many coding and non-coding RNAs and influence their processing. Using Drosophila, we have performed a functional sc...

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Detalles Bibliográficos
Autores principales: Appocher, Chiara, Mohagheghi, Fatemeh, Cappelli, Sara, Stuani, Cristiana, Romano, Maurizio, Feiguin, Fabian, Buratti, Emanuele
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2017
Materias:
RNA
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5570092/
https://www.ncbi.nlm.nih.gov/pubmed/28575377
http://dx.doi.org/10.1093/nar/gkx477

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