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A c-Myb mutant causes deregulated differentiation due to impaired histone binding and abrogated pioneer factor function
The transcription factor c-Myb is involved in early differentiation and proliferation of haematopoietic cells, where it operates as a regulator of self-renewal and multi-lineage differentiation. Deregulated c-Myb plays critical roles in leukaemias and other human cancers. Due to its role as a master...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2017
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5570105/ https://www.ncbi.nlm.nih.gov/pubmed/28472346 http://dx.doi.org/10.1093/nar/gkx364 |