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Cell-type-specific genome editing with a microRNA-responsive CRISPR–Cas9 switch
The CRISPR–Cas9 system is a powerful genome-editing tool useful in a variety of biotechnology and biomedical applications. Here we developed a synthetic RNA-based, microRNA (miRNA)-responsive CRISPR–Cas9 system (miR-Cas9 switch) in which the genome editing activity of Cas9 can be modulated through e...
Autores principales: | Hirosawa, Moe, Fujita, Yoshihiko, Parr, Callum J. C., Hayashi, Karin, Kashida, Shunnichi, Hotta, Akitsu, Woltjen, Knut, Saito, Hirohide |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5570128/ https://www.ncbi.nlm.nih.gov/pubmed/28525578 http://dx.doi.org/10.1093/nar/gkx309 |
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