Piwi interacts with chromatin at nuclear pores and promiscuously binds nuclear transcripts in Drosophila ovarian somatic cells

Piwi in a complex with Piwi-interacting RNAs (piRNAs) triggers transcriptional silencing of transposable elements (TEs) in Drosophila ovaries, thus ensuring genome stability. To do this, Piwi must scan the nascent transcripts of genes and TEs for complementarity to piRNAs. The mechanism of this scan...

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Detalles Bibliográficos
Autores principales: Ilyin, Artem A., Ryazansky, Sergei S., Doronin, Semen A., Olenkina, Oxana M., Mikhaleva, Elena A., Yakushev, Evgeny Y., Abramov, Yuri A., Belyakin, Stepan N., Ivankin, Anton V., Pindyurin, Alexey V., Gvozdev, Vladimir A., Klenov, Mikhail S., Shevelyov, Yuri Y.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2017
Materias:
Gene regulation, Chromatin and Epigenetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5570135/
https://www.ncbi.nlm.nih.gov/pubmed/28472469
http://dx.doi.org/10.1093/nar/gkx355

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