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Hot-spot identification on a broad class of proteins and RNA suggest unifying principles of molecular recognition
Chemically diverse fragments tend to collectively bind at localized sites on proteins, which is a cornerstone of fragment-based techniques. A central question is how general are these strategies for predicting a wide variety of molecular interactions such as small molecule-protein, protein-protein a...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2017
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5570288/ https://www.ncbi.nlm.nih.gov/pubmed/28837642 http://dx.doi.org/10.1371/journal.pone.0183327 |