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Listeriolysin S: A bacteriocin from epidemic Listeria monocytogenes strains that targets the gut microbiota
Listeria monocytogenes is a Gram-positive food-borne pathogen that in humans may traverse the intestinal, placental and blood/brain barriers, causing gastroenteritis, abortions and meningitis. Crossing of these barriers is dependent on the bacterial ability to enter host cells, and several L. monocy...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Taylor & Francis
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5570420/ https://www.ncbi.nlm.nih.gov/pubmed/28156183 http://dx.doi.org/10.1080/19490976.2017.1290759 |
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author | Quereda, Juan J. Meza-Torres, Jazmín Cossart, Pascale Pizarro-Cerdá, Javier |
author_facet | Quereda, Juan J. Meza-Torres, Jazmín Cossart, Pascale Pizarro-Cerdá, Javier |
author_sort | Quereda, Juan J. |
collection | PubMed |
description | Listeria monocytogenes is a Gram-positive food-borne pathogen that in humans may traverse the intestinal, placental and blood/brain barriers, causing gastroenteritis, abortions and meningitis. Crossing of these barriers is dependent on the bacterial ability to enter host cells, and several L. monocytogenes surface and secreted virulence factors are known to facilitate entry and the intracellular lifecycle. The study of L. monocytogenes strains associated to human listeriosis epidemics has revealed the presence of novel virulence factors. One such factor is Listeriolysin S, a thiazole/oxazole modified microcin that displays bactericidal activity and modifies the host microbiota during infection. Our recent results therefore highlight the interaction of L. monocytogenes with gut microbes as a crucial step in epidemic listeriosis. In this article, we will discuss novel implications for this family of toxins in the pathogenesis of diverse medically relevant microorganisms. |
format | Online Article Text |
id | pubmed-5570420 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Taylor & Francis |
record_format | MEDLINE/PubMed |
spelling | pubmed-55704202017-08-29 Listeriolysin S: A bacteriocin from epidemic Listeria monocytogenes strains that targets the gut microbiota Quereda, Juan J. Meza-Torres, Jazmín Cossart, Pascale Pizarro-Cerdá, Javier Gut Microbes Addendum Listeria monocytogenes is a Gram-positive food-borne pathogen that in humans may traverse the intestinal, placental and blood/brain barriers, causing gastroenteritis, abortions and meningitis. Crossing of these barriers is dependent on the bacterial ability to enter host cells, and several L. monocytogenes surface and secreted virulence factors are known to facilitate entry and the intracellular lifecycle. The study of L. monocytogenes strains associated to human listeriosis epidemics has revealed the presence of novel virulence factors. One such factor is Listeriolysin S, a thiazole/oxazole modified microcin that displays bactericidal activity and modifies the host microbiota during infection. Our recent results therefore highlight the interaction of L. monocytogenes with gut microbes as a crucial step in epidemic listeriosis. In this article, we will discuss novel implications for this family of toxins in the pathogenesis of diverse medically relevant microorganisms. Taylor & Francis 2017-02-03 /pmc/articles/PMC5570420/ /pubmed/28156183 http://dx.doi.org/10.1080/19490976.2017.1290759 Text en © 2017 The Author(s).Published with license by Taylor and Francis. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way. |
spellingShingle | Addendum Quereda, Juan J. Meza-Torres, Jazmín Cossart, Pascale Pizarro-Cerdá, Javier Listeriolysin S: A bacteriocin from epidemic Listeria monocytogenes strains that targets the gut microbiota |
title | Listeriolysin S: A bacteriocin from epidemic Listeria monocytogenes strains that targets the gut microbiota |
title_full | Listeriolysin S: A bacteriocin from epidemic Listeria monocytogenes strains that targets the gut microbiota |
title_fullStr | Listeriolysin S: A bacteriocin from epidemic Listeria monocytogenes strains that targets the gut microbiota |
title_full_unstemmed | Listeriolysin S: A bacteriocin from epidemic Listeria monocytogenes strains that targets the gut microbiota |
title_short | Listeriolysin S: A bacteriocin from epidemic Listeria monocytogenes strains that targets the gut microbiota |
title_sort | listeriolysin s: a bacteriocin from epidemic listeria monocytogenes strains that targets the gut microbiota |
topic | Addendum |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5570420/ https://www.ncbi.nlm.nih.gov/pubmed/28156183 http://dx.doi.org/10.1080/19490976.2017.1290759 |
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